ncf2 neutrophil cytosolic factor 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: ncf2provided by Xenbase
Official Full Name: neutrophil cytosolic factor 2provided by Xenbase
Primary source: Xenbase:XB-GENE-482959
See related: Ensembl:ENSXETG00000012530 AllianceGenome:Xenbase:XB-GENE-482959
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: noxa2; p67phox; p67-phox
Summary: Predicted to enable superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to act upstream of or within phagocytosis and respiratory burst. Predicted to be part of NADPH oxidase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease 2; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	4	NC_030680.2 (99916637..99935057)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	4	NC_030680.1 (89703921..89722291)

Chromosome 4 - NC_030680.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NADPH oxidase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory burst	IEA Inferred from Electronic Annotation more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neutrophil cytosol factor 2

Names: neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033947.1 → NP_001029119.1 neutrophil cytosol factor 2

See identical proteins and their annotated locations for NP_001029119.1

Status: PROVISIONAL

Source sequence(s)

BC099979

UniProtKB/TrEMBL

A0A6I8QXJ4, Q499C5

Related

ENSXETP00000078250.2, ENSXETT00000097884.2

Conserved Domains (5) summary

cd11871
Location:245 → 298

SH3_p67phox_N; N-terminal (or first) Src Homology 3 domain of the p67phox subunit of NADPH oxidase

cd12046
Location:469 → 521

SH3_p67phox_C; C-terminal (or second) Src Homology 3 domain of the p67phox subunit of NADPH oxidase

sd00006
Location:37 → 65

TPR; TPR repeat [structural motif]

pfam13414
Location:71 → 149

TPR_11; TPR repeat

cl02720
Location:365 → 442

PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...