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    acsf3 acyl-CoA synthetase family member 3 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100158470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acsf3provided by Xenbase
    Official Full Name
    acyl-CoA synthetase family member 3provided by Xenbase
    Primary source
    Xenbase:XB-GENE-964811
    See related
    Ensembl:ENSXETG00000011261 AllianceGenome:Xenbase:XB-GENE-964811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable ligase activity. Predicted to act upstream of or within fatty acid metabolic process. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See acsf3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (58506819..58549843)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (61046197..61067384)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, nuclear 1-like (cytoplasmic) Neighboring gene CBFA2/RUNX1 translocation partner 3 Neighboring gene cadherin 15 Neighboring gene solute carrier family 22 member 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    malonate--CoA ligase ACSF3, mitochondrial
    NP_001121382.2
    XP_031755731.1
    XP_031755732.1
    XP_031755733.1
    XP_031755734.1
    XP_031755735.1
    XP_031755736.1
    XP_031755737.1
    XP_031755738.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127910.2 → NP_001121382.2  malonate--CoA ligase ACSF3, mitochondrial

      See identical proteins and their annotated locations for NP_001121382.2

      Status: VALIDATED

      Source sequence(s)
      BC122927, BC166077
      UniProtKB/TrEMBL
      A0A8J0QD18, B2GU01
      Related
      ENSXETP00000024596.5, ENSXETT00000024596.5
      Conserved Domains (2) summary
      cd05941
      Location:67 → 579
      MCS; Malonyl-CoA synthetase (MCS)
      COG0318
      Location:61 → 582
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      58506819..58549843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031899876.1 → XP_031755736.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2GU01, F6RXT8
      Conserved Domains (1) summary
      cd05941
      Location:66 → 582
      MCS; Malonyl-CoA synthetase (MCS)

    2. XM_031899872.1 → XP_031755732.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2GU01, F6RXT8
      Conserved Domains (1) summary
      cd05941
      Location:66 → 582
      MCS; Malonyl-CoA synthetase (MCS)

    3. XM_031899877.1 → XP_031755737.1  malonate--CoA ligase ACSF3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8J1JCX5, B2GU01
      Conserved Domains (1) summary
      cd05941
      Location:66 → 550
      MCS; Malonyl-CoA synthetase (MCS)

    4. XM_031899871.1 → XP_031755731.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2GU01, F6RXT8
      Conserved Domains (1) summary
      cd05941
      Location:66 → 582
      MCS; Malonyl-CoA synthetase (MCS)

    5. XM_031899873.1 → XP_031755733.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2GU01, F6RXT8
      Conserved Domains (1) summary
      cd05941
      Location:66 → 582
      MCS; Malonyl-CoA synthetase (MCS)

    6. XM_031899875.1 → XP_031755735.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2GU01, F6RXT8
      Related
      ENSXETP00000098153.2, ENSXETT00000089655.2
      Conserved Domains (1) summary
      cd05941
      Location:66 → 582
      MCS; Malonyl-CoA synthetase (MCS)

    7. XM_031899874.1 → XP_031755734.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2GU01, F6RXT8
      Conserved Domains (1) summary
      cd05941
      Location:66 → 582
      MCS; Malonyl-CoA synthetase (MCS)

    8. XM_031899878.1 → XP_031755738.1  malonate--CoA ligase ACSF3, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8J1JCX3
      Conserved Domains (1) summary
      cd05941
      Location:1 → 348
      MCS; Malonyl-CoA synthetase (MCS)

    RNA

    1. XR_004222172.1 RNA Sequence

    2. XR_004222171.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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