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    Ggamma1 G protein gamma subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ggamma1provided by FlyBase
    Official Full Name
    G protein gamma subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004921
    Locus tag
    Dmel_CG8261
    See related
    AllianceGenome:FB:FBgn0004921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bro4; CG8261; D-G[[gamma]]1; dg1alpha; Dmel\CG8261; G protein gamma; Gbetagamma; Gg1; Ggamma; Ggamma-1; ggamma1; GNG13; G[[gamma1]]; G[[gamma]]; l(2)k08017
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Involved in several processes, including embryonic morphogenesis; heart development; and mesectoderm development. Part of heterotrimeric G-protein complex. Is expressed in several structures, including adult brain; adult heart; female germline cell; ganglia; and organism subdivision. Used to study obesity. Orthologous to several human genes including GNG12 (G protein subunit gamma 12); GNG2 (G protein subunit gamma 2); and GNG7 (G protein subunit gamma 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ggamma1 in Genome Data Viewer
    Location:
    44F3-44F5; 2-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8901404..8904791)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4788909..4792296)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Secretory 31 Neighboring gene anastral spindle 2 Neighboring gene uncharacterized protein Neighboring gene MRG/MORF4L binding protein Neighboring gene Chaperonin containing TCP1 subunit 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organization and expression of the Drosophila melanogaster D-G gamma 1 gene encoding the G-protein gamma subunit. Ray K, et al. Gene, 1994 Oct 21. PMID 7958961
    2. G-protein alpha o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity. Thomas TC, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234290, Free PMC Article
    3. The Drosophila G protein gamma subunit gene (D-G gamma 1) produces three developmentally regulated transcripts and is predominantly expressed in the central nervous system. Ray K, et al. J Biol Chem, 1992 Mar 25. PMID 1372898
    4. The importance of G-protein beta lambda subunits. Iñiguez-Lluhi J, et al. Trends Cell Biol, 1993 Jul. PMID 14731758
    5. Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration. Deshpande G, et al. Development, 2016 Jun 15. PMID 27122170, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Galphaq, Ggamma1 and Plc21C are anti-obesity genes and Akh employs the Galphaq/Ggamma1/Plc21C module of iCa(2+) control to regulate lipid mobilization in adult Drosophila.
      Title: Gαq, Gγ1 and Plc21C control Drosophila body fat storage.
    2. We show that production of this PGC attractant depends upon shf as well as a second hh pathway gene g gamma1.
      Title: The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration.
    3. findings show that Ggamma1 is a component of the Hedgehog signaling pathway & is required for the efficient release of the Hh ligand from hh expressing cells; also Ggamma1 is required for germ cell migration
      Title: Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration.
    4. Study shows that G-oalpha47A and Gbeta13F cooperate with Ggamma1 to maintain cardiac integrity in Drosophila.
      Title: Heterotrimeric G proteins regulate a noncanonical function of septate junction proteins to maintain cardiac integrity in Drosophila.
    5. Data identify a mutant in the Ggamma1 subunit of heterotrimeric G protein, which produces Ggamma1 lacking its membrane anchor site and exhibits phenotypes identical to those of Gbeta13F, including abnormal spindle asymmetry and spindle orientation.
      Title: Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division.
    6. findings reveal a cardial cell-autonomous requirement of Ggamma1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in congenital heart disease
      Title: The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1.
    7. G-protein gamma subunit 1 participates in the signal transduction of sugar taste reception
      Title: G-protein gamma subunit 1 is required for sugar reception in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apical protein localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in convergent extension involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cytoskeleton polarity involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proboscis extension reflex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myosin II filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G protein gamma subunit 1
    Names
    CG8261-PA
    CG8261-PB
    CG8261-PC
    G protein Gg1
    G protein gamma 1
    G protein gamma1
    G protein subunit gamma1
    G-protein gamma subunit 1
    Ggamma1-PA
    Ggamma1-PB
    Ggamma1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8901404..8904791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078938.3 → NP_523662.1  G protein gamma subunit 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ90, P38040, Q540Y8, Q9V4Z3
      Related
      FBpp0087728
      Conserved Domains (1) summary
      cd00068
      Location:8 → 65
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    2. NM_165631.2 → NP_724718.1  G protein gamma subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ90, P38040, Q540Y8, Q9V4Z3
      Related
      FBpp0087726
      Conserved Domains (1) summary
      cd00068
      Location:8 → 65
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    3. NM_165632.2 → NP_724719.1  G protein gamma subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ90, P38040, Q540Y8, Q9V4Z3
      Related
      FBpp0087727
      Conserved Domains (1) summary
      cd00068
      Location:8 → 65
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38040.1 P38040

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