Fib Fibrillarin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fibprovided by FlyBase
Official Full Name: Fibrillarinprovided by FlyBase
Primary source: FLYBASE:FBgn0003062
Locus tag: Dmel_CG9888
See related: AllianceGenome:FB:FBgn0003062
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9888; dFib; Dmel\CG9888; fib; Fibri; fibrillarin; GCR-6; GCR6; pen59C5; Pen59C5
Summary: Predicted to enable RNA binding activity; histone H2AQ104 methyltransferase activity; and rRNA methyltransferase activity. Predicted to be involved in box C/D sno(s)RNA 3'-end processing and rRNA methylation. Located in Cajal body and nucleolus. Is expressed in several structures, including adult brain; adult head; adult heart; embryonic/larval midgut primordium; and larval muscle cell. Orthologous to several human genes including FBL (fibrillarin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23072909..23074725, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18960432..18962248, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables histone H2AQ104 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in box C/D sno(s)RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	IDA Inferred from Direct Assay more info	PubMed
part_of box C/D methylation guide snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in dense fibrillar component	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info