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    gap-2 Ras GTPase-activating protein gap-2 [ Caenorhabditis elegans ]

    Gene ID: 181172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gap-2
    Official Full Name
    Ras GTPase-activating protein gap-2
    Primary source
    WormBase:WBGene00001516
    Locus tag
    CELE_ZK899.8
    See related
    AllianceGenome:WB:WBGene00001516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in learning or memory and negative regulation of Ras protein signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including head muscle; non-striated muscle; seam cell; tail; and vulva. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 5; lung cancer; prostate cancer; and stomach cancer. Orthologous to several human genes including DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and SYNGAP1 (synaptic Ras GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gap-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (9472470..9516454)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRESAN domain-containing protein Neighboring gene FLYWCH-type domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variants that modify neuroendocrine gene expression and foraging behavior of C. elegans. Lee H, et al. Sci Adv, 2024 Jun 14. PMID 38865452, Free PMC Article
    2. Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3. Stetak A, et al. Dev Biol, 2008 Nov 15. PMID 18805410
    3. Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory. Gyurkó MD, et al. Sci Rep, 2015 Oct 15. PMID 26469632, Free PMC Article
    4. Activation of Ras and the mitogen-activated protein kinase pathway promotes protein degradation in muscle cells of Caenorhabditis elegans. Szewczyk NJ, et al. Mol Cell Biol, 2002 Jun. PMID 12024031, Free PMC Article
    5. Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development. Hayashizaki S, et al. Genes Cells, 1998 Mar. PMID 9619631

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in associative learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in short-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras GTPase-activating protein gap-2
    NP_001123198.1
    • Partially confirmed by transcript evidence
    NP_001294843.1
    • Confirmed by transcript evidence
    NP_001294845.1
    • Confirmed by transcript evidence
    NP_001379449.1
    • Confirmed by transcript evidence
    NP_509594.3
    • Confirmed by transcript evidence
    NP_509595.1
    • Confirmed by transcript evidence
    NP_509596.1
    • Confirmed by transcript evidence
    NP_509597.1
    • Confirmed by transcript evidence
    NP_509598.1
    • Confirmed by transcript evidence
    NP_509599.1
    • Confirmed by transcript evidence
    NP_741873.1
    • Confirmed by transcript evidence
    NP_741874.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9472470..9516454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077193.7 → NP_509594.3  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509594.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZJ45, K8ERX6, K8ERY0, K8ESF6, K8ESL7, K8F7Z7, K8FE04, M1ZJ21, M1ZMJ4, O44239, O44240, O44241, O44242, O44243, O44244, O44245, Q3S1K5, Q8MLZ5, Q9TVD9, Q9TVE0, Q9TVE1, Q9TVE2, Q9TVE3, Q9TVE4, Q9U991, Q9UAH9, Q9UAI0
      Conserved Domains (4) summary
      cd04013
      Location:384 → 534
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:525 → 853
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:512 → 857
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:242 → 442
      PH-like; Pleckstrin homology-like domain

    2. NM_001307916.4 → NP_001294845.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294845.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:384 → 534
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:525 → 853
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:512 → 857
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:242 → 442
      PH-like; Pleckstrin homology-like domain

    3. NM_077194.8 → NP_509595.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:347 → 497
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:488 → 816
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:475 → 820
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:213 → 405
      PH-like; Pleckstrin homology-like domain

    4. NM_077195.8 → NP_509596.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:436 → 586
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:577 → 905
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:564 → 909
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:302 → 494
      PH-like; Pleckstrin homology-like domain

    5. NM_077196.6 → NP_509597.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:314 → 464
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:455 → 783
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:442 → 787
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:180 → 372
      PH-like; Pleckstrin homology-like domain

    6. NM_077197.6 → NP_509598.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:225 → 375
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:366 → 694
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:353 → 698
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:83 → 283
      PH-like; Pleckstrin homology-like domain

    7. NM_171753.7 → NP_741873.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:265 → 415
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:406 → 734
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:393 → 738
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:131 → 323
      PH-like; Pleckstrin homology-like domain

    8. NM_077198.7 → NP_509599.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:133 → 283
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:274 → 602
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:261 → 606
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:27 → 191
      PH-like; Pleckstrin homology-like domain

    9. NM_001307914.4 → NP_001294843.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:125 → 275
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:266 → 594
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:253 → 598
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:55 → 183
      PH-like; Pleckstrin homology-like domain

    10. NM_001392821.1 → NP_001379449.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd04013
      Location:3 → 153
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:144 → 472
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins

    11. NM_001129726.4 → NP_001123198.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (3) summary
      cd05136
      Location:108 → 436
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:95 → 440
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl14603
      Location:73 → 117
      C2; C2 domain

    12. NM_171754.7 → NP_741874.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (3) summary
      cd05136
      Location:105 → 433
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:92 → 437
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl14603
      Location:70 → 114
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLZ5.2

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