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    myo-5 MYOsin heavy chain structural genes [ Caenorhabditis elegans ]

    Gene ID: 179190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo-5
    Official Full Name
    MYOsin heavy chain structural genes
    Primary source
    WormBase:WBGene00019064
    Locus tag
    CELE_F58G4.1
    See related
    AllianceGenome:WB:WBGene00019064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in sarcomere. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in pharynx. Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See myo-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (8108970..8118131)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Glycosyltransferase family 92 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans. Lazakovitch E, et al. Dev Dyn, 2008 Aug. PMID 18651662
    2. Cell-specific proteomic analysis in Caenorhabditis elegans. Yuet KP, et al. Proc Natl Acad Sci U S A, 2015 Mar 3. PMID 25691744, Free PMC Article
    3. The effects of plant cysteine proteinases on the nematode cuticle. Njom VS, et al. Parasit Vectors, 2021 Jun 5. PMID 34090505, Free PMC Article
    4. Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization. Watterson A, et al. Cell Rep, 2022 Oct 18. PMID 36261024, Free PMC Article
    5. The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. Bailly AP, et al. Cell Rep, 2019 Oct 1. PMID 31577950, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anatomical structure formation involved in morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular component assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MYOsin heavy chain structural genes
    NP_505094.1
    • Product from WormBase gene class myo;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8108970..8118131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072693.4 → NP_505094.1  MYOsin heavy chain structural genes [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21000
      Conserved Domains (8) summary
      cd01377
      Location:95 → 776
      MYSc_class_II; class II myosins, motor domain
      pfam00063
      Location:83 → 776
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:853 → 1933
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:31 → 68
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam10267
      Location:1212 → 1322
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
      pfam16043
      Location:954 → 1129
      DUF4795; Domain of unknown function (DUF4795)
      cl09111
      Location:1111 → 1243
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl19849
      Location:1746 → 1838
      DUF881; Bacterial protein of unknown function (DUF881)
    Nucleotide Protein
    Heading Accession and Version

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