R02F2.1 Cyclin-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: R02F2.1
Official Full Name: Cyclin-like domain-containing protein
Primary source: WormBase:WBGene00019831
Locus tag: CELE_R02F2.1
See related: AllianceGenome:WB:WBGene00019831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); localized osteosarcoma; ovarian cancer (multiple); and sarcoma. Orthologous to several human genes including CCNI (cyclin I). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R02F2.1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (5501885..5506400)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R02F2.1 (e-PCR)
- UniSTS:312029

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cyclin-like domain-containing protein

NP_001359962.1

Confirmed by transcript evidence

NP_498175.1

Confirmed by transcript evidence

NP_498176.1

Confirmed by transcript evidence

NP_871676.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5501885..5506400

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001372588.3 → NP_001359962.1 Cyclin-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8IFZ9

Conserved Domains (1) summary

cl00050
Location:55 → 154

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_065774.6 → NP_498175.1 Cyclin-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498175.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZJ3

Conserved Domains (1) summary

cl00050
Location:55 → 154

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_065775.7 → NP_498176.1 Cyclin-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498176.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KZJ2

Conserved Domains (1) summary

cl00050
Location:55 → 154

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_181947.8 → NP_871676.1 Cyclin-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871676.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IFZ8

Conserved Domains (1) summary

cl00050
Location:36 → 135

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...