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    uev-2 UBC core domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186377, updated on 27-Dec-2024

    Summary

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    Official Symbol
    uev-2
    Official Full Name
    UBC core domain-containing protein
    Primary source
    WormBase:WBGene00006731
    Locus tag
    CELE_F56D2.4
    See related
    AllianceGenome:WB:WBGene00006731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uev-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5583125..5584522)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene DUF4440 domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aging and sperm signals alter DNA break formation and repair in the C. elegans germline. Toraason E, et al. PLoS Genet, 2022 Nov. PMID 36342909, Free PMC Article
    2. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Howard RA, et al. BMC Cell Biol, 2007 Jul 30. PMID 17663792, Free PMC Article
    3. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
    4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBC core domain-containing protein
    NP_498198.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5583125..5584522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065797.3 → NP_498198.1  UBC core domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20872
      Conserved Domains (1) summary
      pfam00179
      Location:40 → 180
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version

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