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    MYO10 myosin X [ Bos taurus (domestic cattle) ]

    Gene ID: 281935, updated on 1-Jan-2025

    Summary

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    Official Symbol
    MYO10provided by VGNC
    Official Full Name
    myosin Xprovided by VGNC
    Primary source
    VGNC:VGNC:31811
    See related
    BGD:BT15025; Ensembl:ENSBTAG00000020126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See MYO10 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (56234281..56495822)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100849043 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132343249 Neighboring gene reticulophagy regulator 1 Neighboring gene zinc finger protein 622

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip. Baboolal TG, et al. J Biol Chem, 2016 Oct 21. PMID 27566544, Free PMC Article
    2. Stable single α-helices are constant force springs in proteins. Wolny M, et al. J Biol Chem, 2014 Oct 3. PMID 25122759, Free PMC Article
    3. Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load. Takagi Y, et al. Proc Natl Acad Sci U S A, 2014 May 6. PMID 24753602, Free PMC Article
    4. Phospholipid-dependent regulation of the motor activity of myosin X. Umeki N, et al. Nat Struct Mol Biol, 2011 Jun 12. PMID 21666676
    5. The stepping pattern of myosin X is adapted for processive motility on bundled actin. Ricca BL, et al. Biophys J, 2010 Sep 22. PMID 20858426, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip.
      Title: A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip.
    2. Single alpha-helices domain of MYO10 unfolds progressively as the length is increased and refolds progressively as the length is reduced.
      Title: Stable single α-helices are constant force springs in proteins.
    3. At low optical trap loads, we observed staircase-like processive movements of myosin-10 interacting with the actin filament, consisting of up to six approximately 35-nm steps per binding interaction.
      Title: Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.
    4. Myosin X is monomeric and the band 4.1-ezrin-radixin-moesin (FERM) and pleckstrin homology (PH) domains bind to the head intramolecularly, forming an inhibited conformation.
      Title: Phospholipid-dependent regulation of the motor activity of myosin X.
    5. the structural features of the motor and the track that allow myosin X to recognize actin filament bundles
      Title: The stepping pattern of myosin X is adapted for processive motility on bundled actin.
    6. myosin X recognizes the local structural arrangement of filaments in long bundles, providing a mechanism for sorting cargo to distant target sites.
      Title: A myosin motor that selects bundled actin for motility.
    7. the predicted coiled coil of myosin 10 forms a novel elongated structure in which the proximal region is a SAH domain and the distal region is a SAH domain (or has an unknown extended structure) that dimerizes only at its end
      Title: The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head.
    8. kinetic analysis of function of Myosin X as a high duty ratio motor
      Title: Myosin X is a high duty ratio motor.
    9. myosin X is a membrane-associated molecular motor
      Title: Mechanism of action of myosin X, a membrane-associated molecular motor.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables plus-end directed microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174394.2 → NP_776819.1  unconventional myosin-X

      See identical proteins and their annotated locations for NP_776819.1

      Status: PROVISIONAL

      Source sequence(s)
      U55042
      UniProtKB/Swiss-Prot
      P79114
      UniProtKB/TrEMBL
      A0A3Q1MCY3
      Related
      ENSBTAP00000068238.2, ENSBTAT00000069817.2
      Conserved Domains (14) summary
      smart00015
      Location:741 → 763
      IQ; Calmodulin-binding motif
      smart00139
      Location:1543 → 1689
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:58 → 739
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1698 → 1952
      B41; Band 4.1 homologues
      cd13202
      Location:1948 → 2036
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:1209 → 1310
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:1375 → 1500
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd14873
      Location:77 → 727
      MYSc_Myo10; class X myosin, motor domain
      pfam00169
      Location:1209 → 1302
      PH; PH domain
      pfam00373
      Location:1790 → 1952
      FERM_M; FERM central domain
      pfam16735
      Location:884 → 934
      MYO10_CC; Unconventional myosin-X coiled coil domain
      cl00155
      Location:1702 → 1747
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:1175 → 1217
      PH-like; Pleckstrin homology-like domain
      cl24005
      Location:848 → 910
      DUF2570; Protein of unknown function (DUF2570)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      56234281..56495822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79114.1 GenPept UniProtKB/Swiss-Prot:P79114

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