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    nra-1 Nicotinic receptor-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 178508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nra-1
    Official Full Name
    Nicotinic receptor-associated protein 1
    Primary source
    WormBase:WBGene00012128
    Locus tag
    CELE_T28F3.1
    See related
    AllianceGenome:WB:WBGene00012128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity. Involved in receptor localization to synapse. Located in plasma membrane. Is expressed in body wall musculature; head neurons; tail neurons; and ventral cord neurons. Orthologous to several human genes including CPNE5 (copine 5) and CPNE9 (copine family member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nra-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (17281455..17284199, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Heat shock protein hsp-1 Neighboring gene ncRNA Neighboring gene Zinc transporter zipt-7.1 Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans. Li Q, et al. Elife, 2020 Nov 24. PMID 33228848, Free PMC Article
    2. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
    3. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nicotinic receptor-associated protein 1
    NP_503069.1
    • Confirmed by transcript evidence
    NP_872104.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17281455..17284199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070668.6 → NP_503069.1  Nicotinic receptor-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4F4, Q9XUB9
      Conserved Domains (3) summary
      cd04047
      Location:174 → 297
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:15 → 149
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:310 → 569
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

    2. NM_182304.4 → NP_872104.1  Nicotinic receptor-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUB9
      Conserved Domains (3) summary
      cd04047
      Location:174 → 285
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:15 → 149
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:298 → 557
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUB9.1

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