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    R12E2.13 MIR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R12E2.13
    Official Full Name
    MIR domain-containing protein
    Primary source
    WormBase:WBGene00020038
    Locus tag
    CELE_R12E2.13
    See related
    AllianceGenome:WB:WBGene00020038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Acts upstream of or within IRE1-mediated unfolded protein response. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to several human genes including SDF2 (stromal cell derived factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R12E2.13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (4177305..4178447, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein bS6m Neighboring gene MPN domain-containing protein Neighboring gene ncRNA Neighboring gene SUN domain-containing protein Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    MIR domain-containing protein
    NP_491320.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4177305..4178447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058919.5 → NP_491320.1  MIR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61793
      Conserved Domains (2) summary
      smart00472
      Location:85 → 141
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      pfam02815
      Location:34 → 180
      MIR; MIR domain
    Nucleotide Protein
    Heading Accession and Version

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