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    tba-5 Tubulin alpha chain [ Caenorhabditis elegans ]

    Gene ID: 184569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tba-5
    Official Full Name
    Tubulin alpha chain
    Primary source
    WormBase:WBGene00006531
    Locus tag
    CELE_F16D3.1
    See related
    AllianceGenome:WB:WBGene00006531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in axonemal microtubule. Is expressed in amphid neurons and phasmid neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tba-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8353382..8358273)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase Neighboring gene SAC domain-containing protein Neighboring gene putative cytochrome P450 CYP36A1 Neighboring gene Tudor domain-containing protein Neighboring gene Tubulin-specific chaperone D Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene PQ-loop repeat-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments. Hao L, et al. Nat Cell Biol, 2011 Jun 5. PMID 21642982, Free PMC Article
    2. Expression Patterns and Levels of All Tubulin Isotypes Analyzed in GFP Knock-In C. elegans Strains. Nishida K, et al. Cell Struct Funct, 2021 Jun 30. PMID 33967119, Free PMC Article
    3. Mutations of a redundant alpha-tubulin gene affect Caenorhabditis elegans early embryonic cleavage via MEI-1/katanin-dependent and -independent pathways. Lu C, et al. Genetics, 2005 May. PMID 15781712, Free PMC Article
    4. Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function. Power KM, et al. PLoS Genet, 2020 Oct. PMID 33064774, Free PMC Article
    5. A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans. Maurya AK, et al. Curr Biol, 2019 Apr 22. PMID 30955935, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Continual transport of sub-stoichiometric numbers of these TBB-4/TBA-5 subunits by the kinesin-2 dependent intraflagellar transport machinery can maintain sensory cilia at their steady-state length.
      Title: Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments.
    2. Embryo expresses redundant alpha- and beta-tubulin isoforms, they nevertheless have subtle functional specializations.
      Title: Mutations of a redundant alpha-tubulin gene affect Caenorhabditis elegans early embryonic cleavage via MEI-1/katanin-dependent and -independent pathways.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tubulin alpha chain
    NP_492268.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8353382..8358273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059867.3 → NP_492268.1  Tubulin alpha chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19490
      Conserved Domains (2) summary
      PTZ00335
      Location:1 → 446
      PTZ00335; tubulin alpha chain; Provisional
      cd02186
      Location:2 → 435
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version

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