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    PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Delphinapterus leucas (beluga whale) ]

    Gene ID: 111179235, updated on 15-Mar-2024

    Summary

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    Gene symbol
    PIK3CB
    Gene description
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
    See related
    Ensembl:ENSDLEG00000000922
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Delphinapterus leucas
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3CB in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098010.1 (10069380..10259342, complement)
    100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160883.1 (5985591..6175550, complement)

    NW_022098010.1Genomic Context describing neighboring genes Neighboring gene TM2 domain-containing protein 1 pseudogene Neighboring gene centrosomal protein 70 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene trafficking protein particle complex subunit 1 pseudogene Neighboring gene forkhead box L2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM228892v3 Primary Assembly

    Genomic

    1. NW_022098010.1 Reference ASM228892v3 Primary Assembly

      Range
      10069380..10259342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022582608.2 → XP_022438316.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A2Y9NZC3
      Related
      ENSDLEP00000001065.1, ENSDLET00000001234.1
      Conserved Domains (5) summary
      cd08693
      Location:318 → 495
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:35 → 112
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cd00872
      Location:526 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:700 → 1061
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
      pfam00794
      Location:174 → 282
      PI3K_rbd; PI3-kinase family, ras-binding domain

    2. XM_030761527.1 → XP_030617387.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A2Y9NZC3
      Conserved Domains (5) summary
      cd08693
      Location:318 → 495
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:35 → 112
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cd00872
      Location:526 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:700 → 1061
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
      pfam00794
      Location:174 → 282
      PI3K_rbd; PI3-kinase family, ras-binding domain

    3. XM_030761528.1 → XP_030617388.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A2Y9NZC3
      Conserved Domains (5) summary
      cd08693
      Location:318 → 495
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00143
      Location:35 → 112
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cd00872
      Location:526 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:700 → 1061
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
      pfam00794
      Location:174 → 282
      PI3K_rbd; PI3-kinase family, ras-binding domain

    4. XM_030761529.1 → XP_030617389.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

      UniProtKB/TrEMBL
      A0A7F8K7E6
      Conserved Domains (5) summary
      cd08693
      Location:267 → 444
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      cd00872
      Location:475 → 645
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05173
      Location:649 → 1010
      PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
      pfam00794
      Location:123 → 231
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl02483
      Location:1 → 61
      PI3K_p85B; PI3-kinase family, p85-binding domain
    Nucleotide Protein
    Heading Accession and Version

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