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    IKZF5 IKAROS family zinc finger 5 [ Homo sapiens (human) ]

    Gene ID: 64376, updated on 9-Dec-2024

    Summary

    Official Symbol
    IKZF5provided by HGNC
    Official Full Name
    IKAROS family zinc finger 5provided by HGNC
    Primary source
    HGNC:HGNC:14283
    See related
    Ensembl:ENSG00000095574 MIM:606238; AllianceGenome:HGNC:14283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THC7; PEGASUS; ZNFN1A5
    Summary
    Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.4), testis (RPKM 7.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See IKZF5 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122990806..123008795, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123865801..123883913, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124750322..124768311, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4143 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene ReSE screen-validated silencer GRCh37_chr10:124760713-124760899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4145 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:124776916-124777782 Neighboring gene Sharpr-MPRA regulatory region 2783 Neighboring gene acyl-CoA dehydrogenase short/branched chain Neighboring gene Sharpr-MPRA regulatory region 13327 Neighboring gene VISTA enhancer hs1319 Neighboring gene VISTA enhancer hs329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124878267-124878768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124878769-124879268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4146 Neighboring gene Sharpr-MPRA regulatory region 13916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:124894701-124895651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124896834-124897798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124898839-124899608 Neighboring gene H6 family homeobox 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13226, FLJ22973, FLJ30945, DKFZp781B0249

    General protein information

    Preferred Names
    zinc finger protein Pegasus
    Names
    zinc finger protein, subfamily 1A, 5 (Pegasus)
    zinc finger transcription factor Pegasus

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_067239.1 RefSeqGene

      Range
      5001..22989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1429

    mRNA and Protein(s)

    1. NM_001271840.1NP_001258769.1  zinc finger protein Pegasus isoform 1

      See identical proteins and their annotated locations for NP_001258769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC073585, AI560579, DA218215
      Consensus CDS
      CCDS41574.1
      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Related
      ENSP00000478056.1, ENST00000617859.4
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001372123.1NP_001359052.1  zinc finger protein Pegasus isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Consensus CDS
      CCDS41574.1
      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Related
      ENSP00000357881.5, ENST00000368886.10
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001372124.1NP_001359053.1  zinc finger protein Pegasus isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Conserved Domains (3) summary
      sd00017
      Location:1636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:5680
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:148284
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    4. NM_001372125.1NP_001359054.1  zinc finger protein Pegasus isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Consensus CDS
      CCDS41574.1
      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001372126.1NP_001359055.1  zinc finger protein Pegasus isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Consensus CDS
      CCDS41574.1
      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    6. NM_001372127.1NP_001359056.1  zinc finger protein Pegasus isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Consensus CDS
      CCDS41574.1
      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001372128.1NP_001359057.1  zinc finger protein Pegasus isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Consensus CDS
      CCDS41574.1
      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    8. NM_001372129.1NP_001359058.1  zinc finger protein Pegasus isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Conserved Domains (3) summary
      sd00017
      Location:1636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:5680
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:148284
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    9. NM_001372130.1NP_001359059.1  zinc finger protein Pegasus isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Conserved Domains (3) summary
      sd00017
      Location:1636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:5680
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:148284
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    10. NM_001372131.1NP_001359060.1  zinc finger protein Pegasus isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC073585
      Conserved Domains (3) summary
      sd00017
      Location:1636
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:5680
      zf-H2C2_2; Zinc-finger double domain
      NF033913
      Location:148284
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      122990806..123008795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425646.1XP_047281602.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
    2. XM_047425647.1XP_047281603.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
    3. XM_006717947.5XP_006718010.1  zinc finger protein Pegasus isoform X1

      See identical proteins and their annotated locations for XP_006718010.1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
      Conserved Domains (3) summary
      PHA03269
      Location:251361
      PHA03269; envelope glycoprotein C; Provisional
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:124148
      zf-H2C2_2; Zinc-finger double domain
    4. XM_047425645.1XP_047281601.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      123865801..123883913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366585.1XP_054222560.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
    2. XM_054366586.1XP_054222561.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
    3. XM_054366587.1XP_054222562.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7
    4. XM_054366584.1XP_054222559.1  zinc finger protein Pegasus isoform X1

      UniProtKB/Swiss-Prot
      B3KVH7, D3DRE7, Q9H2T0, Q9H5V7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_073476.2: Suppressed sequence

      Description
      NR_073476.2: This RefSeq was removed because it is now thought that this transcript does encode a protein.