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    L3mbtl1 L3MBTL1 histone methyl-lysine binding protein [ Mus musculus (house mouse) ]

    Gene ID: 241764, updated on 27-Nov-2024

    Summary

    Official Symbol
    L3mbtl1provided by MGI
    Official Full Name
    L3MBTL1 histone methyl-lysine binding proteinprovided by MGI
    Primary source
    MGI:MGI:2676663
    See related
    Ensembl:ENSMUSG00000035576 AllianceGenome:MGI:2676663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L3mbtl; mKIAA0681; C630004G01
    Summary
    Predicted to enable several functions, including SAM domain binding activity; identical protein binding activity; and nucleosome binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule biosynthetic process; regulation of megakaryocyte differentiation; and regulation of mitotic nuclear division. Predicted to be located in chromatin; condensed chromosome; and nucleoplasm. Predicted to be part of chromatin lock complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; central nervous system; early embryo; genitourinary system; and sensory organ. Orthologous to human L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.6), CNS E18 (RPKM 2.4) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See L3mbtl1 in Genome Data Viewer
    Location:
    2 H2; 2 83.88 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162784260..162819726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162942333..162977806)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CDGSH iron sulfur domain 3B Neighboring gene STARR-seq mESC enhancer starr_06291 Neighboring gene STARR-positive B cell enhancer ABC_E7882 Neighboring gene serine and arginine-rich splicing factor 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene serum/glucocorticoid regulated kinase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0681

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SAM domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epigenetic regulation of gene expression NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of chromatin lock complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    lethal(3)malignant brain tumor-like protein 1
    Names
    H-l(3)mbt protein
    L(3)mbt protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081338.3NP_001074807.1  lethal(3)malignant brain tumor-like protein 1

      See identical proteins and their annotated locations for NP_001074807.1

      Status: VALIDATED

      Source sequence(s)
      AL591584, AL606473
      Consensus CDS
      CCDS38314.1
      UniProtKB/Swiss-Prot
      A2A5N8, Q5DU20
      Related
      ENSMUSP00000044038.6, ENSMUST00000035751.12
      Conserved Domains (3) summary
      cd09582
      Location:754819
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162784260..162819726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251189.2XP_030107049.1  lethal(3)malignant brain tumor-like protein 1 isoform X11

      Conserved Domains (1) summary
      smart00561
      Location:283380
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    2. XM_030251184.2XP_030107044.1  lethal(3)malignant brain tumor-like protein 1 isoform X6

      Conserved Domains (3) summary
      smart00561
      Location:464556
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:592620
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:719752
      SAM_superfamily; SAM (Sterile alpha motif )
    3. XM_030251175.2XP_030107035.1  lethal(3)malignant brain tumor-like protein 1 isoform X2

      Conserved Domains (3) summary
      smart00561
      Location:498590
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:626654
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:753786
      SAM_superfamily; SAM (Sterile alpha motif )
    4. XM_030251174.2XP_030107034.1  lethal(3)malignant brain tumor-like protein 1 isoform X1

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754787
      SAM_superfamily; SAM (Sterile alpha motif )
    5. XM_011239544.4XP_011237846.1  lethal(3)malignant brain tumor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237846.1

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754787
      SAM_superfamily; SAM (Sterile alpha motif )
    6. XM_011239540.4XP_011237842.1  lethal(3)malignant brain tumor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237842.1

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754787
      SAM_superfamily; SAM (Sterile alpha motif )
    7. XM_011239541.4XP_011237843.1  lethal(3)malignant brain tumor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237843.1

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754787
      SAM_superfamily; SAM (Sterile alpha motif )
    8. XM_011239543.4XP_011237845.1  lethal(3)malignant brain tumor-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237845.1

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754787
      SAM_superfamily; SAM (Sterile alpha motif )
    9. XM_030251183.2XP_030107043.1  lethal(3)malignant brain tumor-like protein 1 isoform X5

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754807
      SAM_superfamily; SAM (Sterile alpha motif )
    10. XM_030251179.2XP_030107039.1  lethal(3)malignant brain tumor-like protein 1 isoform X4

      Conserved Domains (3) summary
      cd09582
      Location:753818
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:498590
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:626654
      zf-C2HC; Zinc finger, C2HC type
    11. XM_036162017.1XP_036017910.1  lethal(3)malignant brain tumor-like protein 1 isoform X7

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754782
      SAM_superfamily; SAM (Sterile alpha motif )
    12. XM_036162019.1XP_036017912.1  lethal(3)malignant brain tumor-like protein 1 isoform X7

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754782
      SAM_superfamily; SAM (Sterile alpha motif )
    13. XM_030251190.2XP_030107050.1  lethal(3)malignant brain tumor-like protein 1 isoform X13

      Conserved Domains (4) summary
      smart00561
      Location:77169
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:205233
      zf-C2HC; Zinc finger, C2HC type
      pfam02820
      Location:269
      MBT; mbt repeat
      cl15755
      Location:332365
      SAM_superfamily; SAM (Sterile alpha motif )
    14. XM_030251188.2XP_030107048.1  lethal(3)malignant brain tumor-like protein 1 isoform X9

      Conserved Domains (3) summary
      cd09582
      Location:719784
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:464556
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:592620
      zf-C2HC; Zinc finger, C2HC type
    15. XM_030251186.2XP_030107046.1  lethal(3)malignant brain tumor-like protein 1 isoform X8

      Conserved Domains (3) summary
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:754784
      SAM_superfamily; SAM (Sterile alpha motif )
    16. XM_030251176.2XP_030107036.1  lethal(3)malignant brain tumor-like protein 1 isoform X3

      UniProtKB/Swiss-Prot
      A2A5N8, Q5DU20
      Conserved Domains (3) summary
      cd09582
      Location:754819
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:499591
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:627655
      zf-C2HC; Zinc finger, C2HC type
    17. XM_036162028.1XP_036017921.1  lethal(3)malignant brain tumor-like protein 1 isoform X13

      Conserved Domains (4) summary
      smart00561
      Location:77169
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:205233
      zf-C2HC; Zinc finger, C2HC type
      pfam02820
      Location:269
      MBT; mbt repeat
      cl15755
      Location:332365
      SAM_superfamily; SAM (Sterile alpha motif )
    18. XM_036162021.1XP_036017914.1  lethal(3)malignant brain tumor-like protein 1 isoform X10

      Conserved Domains (4) summary
      cd09582
      Location:439504
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:184276
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:312340
      zf-C2HC; Zinc finger, C2HC type
      pfam02820
      Location:269
      MBT; mbt repeat
    19. XM_011239553.3XP_011237855.1  lethal(3)malignant brain tumor-like protein 1 isoform X12

      See identical proteins and their annotated locations for XP_011237855.1

      Conserved Domains (3) summary
      smart00561
      Location:98190
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:226254
      zf-C2HC; Zinc finger, C2HC type
      cl15755
      Location:353386
      SAM_superfamily; SAM (Sterile alpha motif )

    RNA

    1. XR_003952994.2 RNA Sequence

    2. XR_374471.5 RNA Sequence