Cyrib CYFIP related Rac1 interactor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyribprovided by MGI
Official Full Name: CYFIP related Rac1 interactor Bprovided by MGI
Primary source: MGI:MGI:1923520
See related: Ensembl:ENSMUSG00000022378 AllianceGenome:MGI:1923520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam49b; 0910001A06Rik
Summary: Enables MHC class Ib protein binding, via antigen binding activity groove. Involved in several processes, including positive regulation of T cell mediated cytotoxicity; positive regulation of memory T cell activation; and positive regulation of type II interferon production. Located in cilium. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 24.7), cerebellum adult (RPKM 18.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 28.16 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (63800943..63932627, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (63929094..64060778, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells.
Title: Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells.
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
Title: CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
Title: Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.
Title: FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class Ib protein binding, via antigen binding groove	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to molecule of bacterial origin	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of small GTPase mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small GTPase mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of memory T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CYFIP-related Rac1 interactor B

Names: family with sequence similarity 49, member B; protein FAM49B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360035.1 → NP_001346964.1 CYFIP-related Rac1 interactor B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1. 2, 3, and 4 encode the same protein.

Source sequence(s)

AC140673, AC156573

Consensus CDS

CCDS27505.1

UniProtKB/Swiss-Prot

Q921M7

Related

ENSMUSP00000132486.2, ENSMUST00000164532.3

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
NM_001360036.1 → NP_001346965.1 CYFIP-related Rac1 interactor B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.

Source sequence(s)

AC140673, AC156573

Consensus CDS

CCDS27505.1

UniProtKB/Swiss-Prot

Q921M7

Related

ENSMUSP00000154320.2, ENSMUST00000228226.2

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
NM_001360037.1 → NP_001346966.1 CYFIP-related Rac1 interactor B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.z

Source sequence(s)

AC140673, AC156573

Consensus CDS

CCDS27505.1

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
NM_001360038.1 → NP_001346967.1 CYFIP-related Rac1 interactor B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a alternate AUG and result in an isoform (2) with a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC140673, AC156573

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
NM_144846.5 → NP_659095.1 CYFIP-related Rac1 interactor B isoform 1

See identical proteins and their annotated locations for NP_659095.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.

Source sequence(s)

AK028062, BX527479, CK633763

Consensus CDS

CCDS27505.1

UniProtKB/Swiss-Prot

Q921M7

Related

ENSMUSP00000066359.5, ENSMUST00000063838.11

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

63800943..63932627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248469.1 → XP_030104329.1 CYFIP-related Rac1 interactor B isoform X2

Conserved Domains (2) summary

PRK12323
Location:1 → 91

PRK12323; DNA polymerase III subunit gamma/tau

pfam07159
Location:109 → 404

DUF1394; Protein of unknown function (DUF1394)
XM_030248468.1 → XP_030104328.1 CYFIP-related Rac1 interactor B isoform X1

Conserved Domains (2) summary

PRK12323
Location:1 → 129

PRK12323; DNA polymerase III subunit gamma/tau

pfam07159
Location:121 → 417

DUF1394; Protein of unknown function (DUF1394)
XM_030248475.1 → XP_030104335.1 CYFIP-related Rac1 interactor B isoform X4

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248470.2 → XP_030104330.1 CYFIP-related Rac1 interactor B isoform X3

Conserved Domains (2) summary

PRK12323
Location:1 → 108

PRK12323; DNA polymerase III subunit gamma/tau

pfam07159
Location:104 → 400

DUF1394; Protein of unknown function (DUF1394)
XM_030248471.2 → XP_030104331.1 CYFIP-related Rac1 interactor B isoform X4

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248472.1 → XP_030104332.1 CYFIP-related Rac1 interactor B isoform X4

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_036159327.1 → XP_036015220.1 CYFIP-related Rac1 interactor B isoform X5

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_036159326.1 → XP_036015219.1 CYFIP-related Rac1 interactor B isoform X4

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248477.2 → XP_030104337.1 CYFIP-related Rac1 interactor B isoform X5

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248474.2 → XP_030104334.1 CYFIP-related Rac1 interactor B isoform X4

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248476.2 → XP_030104336.1 CYFIP-related Rac1 interactor B isoform X5

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_011245564.3 → XP_011243866.1 CYFIP-related Rac1 interactor B isoform X5

See identical proteins and their annotated locations for XP_011243866.1

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_006520763.4 → XP_006520826.1 CYFIP-related Rac1 interactor B isoform X4

See identical proteins and their annotated locations for XP_006520826.1

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248478.1 → XP_030104338.1 CYFIP-related Rac1 interactor B isoform X6

Conserved Domains (1) summary

pfam07159
Location:1 → 174

DUF1394; Protein of unknown function (DUF1394)
XM_006520764.5 → XP_006520827.1 CYFIP-related Rac1 interactor B isoform X4

See identical proteins and their annotated locations for XP_006520827.1

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_006520766.3 → XP_006520829.1 CYFIP-related Rac1 interactor B isoform X6

See identical proteins and their annotated locations for XP_006520829.1

Conserved Domains (1) summary

pfam07159
Location:1 → 174

DUF1394; Protein of unknown function (DUF1394)
XM_006520762.5 → XP_006520825.1 CYFIP-related Rac1 interactor B isoform X5

See identical proteins and their annotated locations for XP_006520825.1

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_030248473.2 → XP_030104333.1 CYFIP-related Rac1 interactor B isoform X4

UniProtKB/Swiss-Prot

Q921M7

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)
XM_006520765.3 → XP_006520828.1 CYFIP-related Rac1 interactor B isoform X5

See identical proteins and their annotated locations for XP_006520828.1

Conserved Domains (1) summary

pfam07159
Location:18 → 320

DUF1394; Protein of unknown function (DUF1394)