U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Prss51 serine protease 51 [ Mus musculus (house mouse) ]

    Gene ID: 100504162, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss51provided by MGI
    Official Full Name
    serine protease 51provided by MGI
    Primary source
    MGI:MGI:1921465
    See related
    Ensembl:ENSMUSG00000052099 AllianceGenome:MGI:1921465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700007N14Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Orthologous to human PRSS51 (serine protease 51). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 14.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prss51 in Genome Data Viewer
    Location:
    14 D1; 14 33.35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (64322974..64335123)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64085525..64097674)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930578I06 gene Neighboring gene predicted gene, 36410 Neighboring gene retinitis pigmentosa 1 homolog like 1 Neighboring gene serine protease 55 Neighboring gene RIKEN cDNA 4930471C04 gene Neighboring gene serine protease 52

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine protease-like protein 51
    Names
    protease, serine 51

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193631.1NP_001180560.1  serine protease-like protein 51 isoform 1

      See identical proteins and their annotated locations for NP_001180560.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC166997
      Consensus CDS
      CCDS56964.1
      UniProtKB/TrEMBL
      E9PXD1
      Related
      ENSMUSP00000132814.2, ENSMUST00000165710.2
      Conserved Domains (1) summary
      cl21584
      Location:5189
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001347631.1NP_001334560.1  serine protease-like protein 51 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate splice site in the 5' coding region relative to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK005740, AV172114
      Consensus CDS
      CCDS84145.1
      UniProtKB/TrEMBL
      Q9DAL4
      Related
      ENSMUSP00000066111.6, ENSMUST00000063785.12
      Conserved Domains (1) summary
      cl21584
      Location:40171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      64322974..64335123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244872.3XP_011243174.1  serine protease-like protein 51 isoform X1

      See identical proteins and their annotated locations for XP_011243174.1

      UniProtKB/TrEMBL
      A0A286YDY8
      Conserved Domains (1) summary
      smart00020
      Location:73296
      Tryp_SPc; Trypsin-like serine protease
    2. XM_006518308.4XP_006518371.1  serine protease-like protein 51 isoform X2

      See identical proteins and their annotated locations for XP_006518371.1

      UniProtKB/TrEMBL
      A0A286YDY8
      Conserved Domains (1) summary
      smart00020
      Location:3210
      Tryp_SPc; Trypsin-like serine protease
    3. XM_006518312.1XP_006518375.1  serine protease-like protein 51 isoform X3

      See identical proteins and their annotated locations for XP_006518375.1

      UniProtKB/TrEMBL
      E9PXD1
      Conserved Domains (1) summary
      cl21584
      Location:5189
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_006518306.4XP_006518369.1  serine protease-like protein 51 isoform X1

      See identical proteins and their annotated locations for XP_006518369.1

      UniProtKB/TrEMBL
      A0A286YDY8
      Related
      ENSMUSP00000153617.2, ENSMUST00000224112.2
      Conserved Domains (1) summary
      smart00020
      Location:73296
      Tryp_SPc; Trypsin-like serine protease
    5. XM_030247572.1XP_030103432.1  serine protease-like protein 51 isoform X2

      UniProtKB/TrEMBL
      A0A286YDY8
      Conserved Domains (1) summary
      smart00020
      Location:3210
      Tryp_SPc; Trypsin-like serine protease
    6. XM_030247573.1XP_030103433.1  serine protease-like protein 51 isoform X4

      UniProtKB/TrEMBL
      Q9DAL4
      Conserved Domains (1) summary
      cl21584
      Location:40171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    7. XM_030247574.1XP_030103434.1  serine protease-like protein 51 isoform X4

      UniProtKB/TrEMBL
      Q9DAL4
      Conserved Domains (1) summary
      cl21584
      Location:40171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...