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    Zfp286 zinc finger protein 286 [ Mus musculus (house mouse) ]

    Gene ID: 192651, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp286provided by MGI
    Official Full Name
    zinc finger protein 286provided by MGI
    Primary source
    MGI:MGI:2384758
    See related
    Ensembl:ENSMUSG00000047342 AllianceGenome:MGI:2384758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to several human genes including ZNF286A (zinc finger protein 286A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 2.6), CNS E18 (RPKM 2.5) and 12 other tissues See more
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    Genomic context

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    See Zfp286 in Genome Data Viewer
    Location:
    11 B2; 11 38.68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62640003..62680385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62751951..62789506, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 287 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA) Neighboring gene WD repeat and SOCS box-containing 2, pseudogene Neighboring gene zinc finger protein 286, opposite strand Neighboring gene predicted gene, 24151 Neighboring gene tripartite motif-containing 16 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene F-box and WD-40 domain protein 10 Neighboring gene STARR-seq mESC enhancer starr_29719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Horiuchi K, et al. Cell Rep, 2018 Apr 3. PMID 29617656
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC39058

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 286A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364096.1 → NP_001351025.1  zinc finger protein 286A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627097, BB627774
      Conserved Domains (5) summary
      smart00349
      Location:1 → 62
      KRAB; krueppel associated box
      COG5048
      Location:301 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001364097.1 → NP_001351026.1  zinc finger protein 286A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627097
      Conserved Domains (5) summary
      smart00349
      Location:1 → 62
      KRAB; krueppel associated box
      COG5048
      Location:301 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001364098.1 → NP_001351027.1  zinc finger protein 286A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627097
      Consensus CDS
      CCDS88169.1
      UniProtKB/TrEMBL
      Q5SVS7
      Related
      ENSMUSP00000104345.2, ENSMUST00000108705.8
      Conserved Domains (1) summary
      smart00349
      Location:50 → 111
      KRAB; krueppel associated box

    4. NM_001364100.1 → NP_001351029.1  zinc finger protein 286A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627097, BC038632
      Related
      ENSMUST00000145474.8
      Conserved Domains (1) summary
      smart00349
      Location:50 → 111
      KRAB; krueppel associated box

    5. NM_138949.4 → NP_620399.3  zinc finger protein 286A isoform 1

      See identical proteins and their annotated locations for NP_620399.3

      Status: VALIDATED

      Source sequence(s)
      AK031547, AL627097, CJ164719
      Consensus CDS
      CCDS24831.1
      UniProtKB/TrEMBL
      Q8C0E6
      Related
      ENSMUSP00000055517.7, ENSMUST00000054654.13
      Conserved Domains (6) summary
      smart00349
      Location:50 → 111
      KRAB; krueppel associated box
      COG5048
      Location:350 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382 → 402
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:352 → 374
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:50 → 85
      KRAB; KRAB box
      pfam13465
      Location:422 → 447
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62640003..62680385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245695.2 → XP_030101555.1  zinc finger protein 286A isoform X7

      UniProtKB/TrEMBL
      A0A140LIZ8
      Related
      ENSMUSP00000147022.2, ENSMUST00000207597.2
      Conserved Domains (1) summary
      smart00349
      Location:50 → 111
      KRAB; krueppel associated box

    2. XM_030245694.2 → XP_030101554.1  zinc finger protein 286A isoform X6

      Conserved Domains (1) summary
      smart00349
      Location:107 → 168
      KRAB; krueppel associated box

    3. XM_017314347.2 → XP_017169836.1  zinc finger protein 286A isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:234 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:153 → 175
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:140 → 164
      zf-H2C2_2; Zinc-finger double domain

    4. XM_030245693.1 → XP_030101553.1  zinc finger protein 286A isoform X5

      Conserved Domains (4) summary
      COG5048
      Location:234 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:153 → 175
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:140 → 164
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011248814.1 → XP_011247116.1  zinc finger protein 286A isoform X4

      See identical proteins and their annotated locations for XP_011247116.1

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149 → 173
      zf-H2C2_2; Zinc-finger double domain

    6. XM_030245692.2 → XP_030101552.1  zinc finger protein 286A isoform X4

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149 → 173
      zf-H2C2_2; Zinc-finger double domain

    7. XM_030245691.2 → XP_030101551.1  zinc finger protein 286A isoform X4

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149 → 173
      zf-H2C2_2; Zinc-finger double domain

    8. XM_030245690.2 → XP_030101550.1  zinc finger protein 286A isoform X4

      UniProtKB/TrEMBL
      Q8R0E0
      Conserved Domains (4) summary
      COG5048
      Location:243 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:162 → 184
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:149 → 173
      zf-H2C2_2; Zinc-finger double domain

    9. XM_011248815.3 → XP_011247117.1  zinc finger protein 286A isoform X8

      Conserved Domains (4) summary
      COG5048
      Location:316 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:348 → 368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:235 → 257
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:222 → 246
      zf-H2C2_2; Zinc-finger double domain

    10. XM_011248812.3 → XP_011247114.1  zinc finger protein 286A isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:1 → 62
      KRAB; krueppel associated box
      COG5048
      Location:301 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain

    11. XM_036156440.1 → XP_036012333.1  zinc finger protein 286A isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:340 → 500
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:372 → 392
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259 → 281
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:246 → 270
      zf-H2C2_2; Zinc-finger double domain

    12. XM_006532543.3 → XP_006532606.3  zinc finger protein 286A isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:370 → 530
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:289 → 311
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:276 → 300
      zf-H2C2_2; Zinc-finger double domain

    13. XM_011248811.4 → XP_011247113.2  zinc finger protein 286A isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:1 → 62
      KRAB; krueppel associated box
      COG5048
      Location:301 → 461
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:333 → 353
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 242
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:207 → 231
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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