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    Smap1 small ArfGAP 1 [ Mus musculus (house mouse) ]

    Gene ID: 98366, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Smap1provided by MGI
    Official Full Name
    small ArfGAP 1provided by MGI
    Primary source
    MGI:MGI:2138261
    See related
    Ensembl:ENSMUSG00000026155 AllianceGenome:MGI:2138261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700056O10Rik; 4921514B13Rik; 4921525H11Rik
    Summary
    Enables GTPase activator activity and clathrin binding activity. Acts upstream of or within positive regulation of erythrocyte differentiation and regulation of clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in embryo. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smap1 in Genome Data Viewer
    Location:
    1 A5; 1 9.79 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (23883925..23961462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (23844825..23922381, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_00435 Neighboring gene predicted gene 28822 Neighboring gene STARR-seq mESC enhancer starr_00436 Neighboring gene STARR-seq mESC enhancer starr_00437 Neighboring gene STARR-positive B cell enhancer ABC_E4306 Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene family with sequence similarity 135, member A Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene predicted gene, 30756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. Kon S, et al. J Clin Invest, 2013 Mar. PMID 23434593, Free PMC Article
    2. Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. Sumiyoshi M, et al. FEBS Lett, 2015 Sep 14. PMID 26296315
    3. Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. Sato Y, et al. J Biochem, 1998 Jul. PMID 9644265
    4. A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis. Tanabe K, et al. Mol Biol Cell, 2005 Apr. PMID 15659652, Free PMC Article
    5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stromal membrane-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290683.2 → NP_001277612.1  stromal membrane-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001277612.1

      Status: VALIDATED

      Source sequence(s)
      AC121857, AC153649
      Consensus CDS
      CCDS69870.1
      UniProtKB/TrEMBL
      D3YVX4
      Related
      ENSMUSP00000117875.2, ENSMUST00000129254.8

    2. NM_001357395.2 → NP_001344324.1  stromal membrane-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121857, AC123790, AC153649
      Conserved Domains (2) summary
      pfam01412
      Location:20 → 120
      ArfGap; Putative GTPase activating protein for Arf
      pfam09606
      Location:343 → 451
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    3. NM_028534.4 → NP_082810.1  stromal membrane-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_082810.1

      Status: VALIDATED

      Source sequence(s)
      AC121857, AC123790, AC153649
      Consensus CDS
      CCDS14851.1
      UniProtKB/Swiss-Prot
      Q497I6, Q68EF3, Q91VZ6
      Related
      ENSMUSP00000027339.8, ENSMUST00000027339.14
      Conserved Domains (1) summary
      pfam01412
      Location:20 → 120
      ArfGap; Putative GTPase activating protein for Arf

    RNA

    1. NR_110972.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121857, AC153649
      Related
      ENSMUST00000149737.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      23883925..23961462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243880.2 → XP_030099740.1  stromal membrane-associated protein 1 isoform X1

      Conserved Domains (1) summary
      cl28907
      Location:1 → 35
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VZ6.1 GenPept UniProtKB/Swiss-Prot:Q91VZ6

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