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    Usp38 ubiquitin specific peptidase 38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307764, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp38provided by RGD
    Official Full Name
    ubiquitin specific peptidase 38provided by RGD
    Primary source
    RGD:1311974
    See related
    EnsemblRapid:ENSRNOG00000026880 AllianceGenome:RGD:1311974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and protein sequestering activity. Predicted to be involved in several processes, including negative regulation of innate immune response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K33-linked deubiquitination. Predicted to be active in cytosol and nucleus. Orthologous to human USP38 (ubiquitin specific peptidase 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 112.1), Thymus (RPKM 99.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Usp38 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (43910459..43941875)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (27006046..27037449)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (30668258..30699852)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-4-phosphatase type II B Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein S15, pseudogene 8 Neighboring gene uncharacterized LOC120098604 Neighboring gene ribosomal protein L35, pseudogene 11 Neighboring gene GRB2-associated binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  
    is_active_in nucleus  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 38
    Names
    ubiquitin specific protease 38
    NP_001100888.2
    XP_038953655.1
    XP_038953656.1
    XP_063134089.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107418.2NP_001100888.2  ubiquitin carboxyl-terminal hydrolase 38

      Status: VALIDATED

      Source sequence(s)
      AI112444, JAXUCZ010000019
      UniProtKB/TrEMBL
      D3Z8K5
      Related
      ENSRNOP00000031071.4, ENSRNOT00000035084.8
      Conserved Domains (1) summary
      cd02664
      Location:446946
      Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      43910459..43941875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097728.2XP_038953656.1  ubiquitin carboxyl-terminal hydrolase 38 isoform X3

      UniProtKB/TrEMBL
      A6IYG8
      Conserved Domains (2) summary
      COG5077
      Location:390492
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cl02553
      Location:446499
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    2. XM_063278019.1XP_063134089.1  ubiquitin carboxyl-terminal hydrolase 38 isoform X1

    3. XM_039097727.2XP_038953655.1  ubiquitin carboxyl-terminal hydrolase 38 isoform X2

      Conserved Domains (2) summary
      cd02664
      Location:1462
      Peptidase_C19H; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam13423
      Location:46141
      UCH_1; Ubiquitin carboxyl-terminal hydrolase

    RNA

    1. XR_005496654.2 RNA Sequence

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