Rab11 Rab11 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab11provided by FlyBase
Official Full Name: Rab11provided by FlyBase
Primary source: FLYBASE:FBgn0015790
Locus tag: Dmel_CG5771
See related: AllianceGenome:FB:FBgn0015790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF55850; CG5771; Dm Rab11; Dmel\CG5771; DmRab11; dRab11; Drab11; DRab11; DRAB11; l(3)93Bi; l(3)j2D1; O18335; Rab 11; rab-11; Rab-11; Rab-r11; rab11; RAB11; rlr7
Summary: Enables GTPase activating protein binding activity and GTPase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; dorsal closure; and germ cell development. Located in several cellular components, including cytoplasmic vesicle; fusome; and spindle envelope. Colocalizes with centrosome and recycling endosome. Is expressed in several structures, including epithelium; germline cell; imaginal disc; mushroom body; and synaptic neuropil domain. Used to study inflammatory bowel disease and intestinal cancer. Orthologous to several human genes including RAB11A (RAB11A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93B12-93B13; 3-70 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21111408..21116146)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16937130..16941868)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab11 maintains the undifferentiated state of adult midgut precursors via DPP pathway.
Title: Rab11 maintains the undifferentiated state of adult midgut precursors via DPP pathway.
A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.
Title: A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.
Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes.
Title: Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes.
Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Title: Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure.
Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction.
Title: Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction.
Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.
Title: Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.
Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination.
Title: Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination.
A novel function for Rab1 and Rab11 during secretory granule maturation.
Title: A novel function for Rab1 and Rab11 during secretory granule maturation.
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals.
Title: Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals.
Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila.
Title: Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0635 (e-PCR)
- UniSTS:19781

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi vesicle fusion to target membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rab protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antimicrobial peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, amnioserosa morphology change	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure, elongation of leading edge cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Golgi to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatocyte division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in synaptic vesicle endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in cell pole	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
colocalizes_with recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in spindle envelope	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	HDA more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rab11

Names: CG5771-PA; CG5771-PB; Rab-protein 11; Rab11-PA; Rab11-PB; lethal(3)93Bi

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21111408..21116146

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134310.3 → NP_599137.1 Rab11, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599137.1

Status: REVIEWED

UniProtKB/TrEMBL

B8A3X3, O18335, Q8IGH2

Related

FBpp0083413

Conserved Domains (1) summary

cd01868
Location:9 → 173

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
NM_057822.4 → NP_477170.1 Rab11, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477170.1

Status: REVIEWED

UniProtKB/TrEMBL

B8A3X3, O18335, Q8IGH2

Related

FBpp0083414

Conserved Domains (1) summary

cd01868
Location:9 → 173

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25