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    Mp20 Muscle protein 20 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mp20provided by FlyBase
    Official Full Name
    Muscle protein 20provided by FlyBase
    Primary source
    FLYBASE:FBgn0002789
    Locus tag
    Dmel_CG4696
    See related
    AllianceGenome:FB:FBgn0002789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4696; Dmel\CG4696; Dmmp20; DMMP20; mp20; MP20; Tpn
    Summary
    Predicted to enable actin filament binding activity. Involved in myoblast fusion and regulation of myoblast fusion. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; border follicle cell; embryonic/larval esophageal visceral muscle; and muscle cell. Orthologous to human TAGLN (transgelin); TAGLN2 (transgelin 2); and TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mp20 in Genome Data Viewer
    Location:
    49F13-49F13; 2-68 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13246670..13248880)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9134175..9136385)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E14 Neighboring gene long non-coding RNA:CR45278 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the gene for mp20: a Drosophila muscle protein that is not found in asynchronous oscillatory flight muscle. Ayme-Southgate A, et al. J Cell Biol, 1989 Feb. PMID 2537318, Free PMC Article
    2. Testing for asymmetrical gene flow in a Drosophila melanogaster body-size cline. Kennington WJ, et al. Genetics, 2003 Oct. PMID 14573478, Free PMC Article
    3. Differential Expression of Drosophila Transgelins Throughout Development. Vakaloglou KM, et al. Front Cell Dev Biol, 2021. PMID 34322481, Free PMC Article
    4. Nonclinality of molecular variation implicates selection in maintaining a morphological cline of Drosophila melanogaster. Gockel J, et al. Genetics, 2001 May. PMID 11333239, Free PMC Article
    5. High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates. Schlötterer C, et al. Mol Biol Evol, 1998 Oct. PMID 9787433

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    muscle protein 20
    Names
    CG4696-PA
    CG4696-PC
    Mp20-PA
    Mp20-PC
    muscle protein 20 kd
    myophilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13246670..13248880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014522.2 → NP_001014522.2  muscle protein 20, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014522.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P14318
      Conserved Domains (3) summary
      COG5199
      Location:7 → 179
      SCP1; Calponin [Cytoskeleton]
      cd00014
      Location:18 → 121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:158 → 178
      Calponin; Calponin family repeat

    2. NM_057295.4 → NP_476643.1  muscle protein 20, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZF7, P14318, Q1WWC7, Q9V6M7
      Related
      FBpp0086858
      Conserved Domains (3) summary
      COG5199
      Location:7 → 179
      SCP1; Calponin [Cytoskeleton]
      cd00014
      Location:18 → 121
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:158 → 178
      Calponin; Calponin family repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14318.2 P14318

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