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    Chek2 checkpoint kinase 2 [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

    Gene ID: 103750875, updated on 11-Mar-2024

    Summary

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    Gene symbol
    Chek2
    Gene description
    checkpoint kinase 2
    See related
    Ensembl:ENSNGAG00000011754
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nannospalax galili
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
    Orthologs
    human mouse all
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    Genomic context

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    See Chek2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008355982.1 (667011..698506, complement)

    NW_008355982.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene igE-binding protein Neighboring gene 60S ribosomal protein L27a pseudogene Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_008355982 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Chk2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference S.galili_v1.0 Primary Assembly

    Genomic

    1. NW_008355982.1 Reference S.galili_v1.0 Primary Assembly

      Range
      667011..698506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008854152.3 → XP_008852374.1  serine/threonine-protein kinase Chk2 isoform X4

      UniProtKB/TrEMBL
      A0A8C6QVH0
      Related
      ENSNGAP00000008904.1, ENSNGAT00000014412.1
      Conserved Domains (2) summary
      cd00060
      Location:103 → 211
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:223 → 496
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_029556671.1 → XP_029412531.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C6QVH0
      Conserved Domains (2) summary
      cd00060
      Location:132 → 240
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:252 → 507
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_029556672.1 → XP_029412532.1  serine/threonine-protein kinase Chk2 isoform X5

      UniProtKB/TrEMBL
      A0A8C6QVH0
      Conserved Domains (2) summary
      cd00060
      Location:132 → 240
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl21453
      Location:252 → 496
      PKc_like; Protein Kinases, catalytic domain

    4. XM_029556669.1 → XP_029412529.1  serine/threonine-protein kinase Chk2 isoform X1

      UniProtKB/TrEMBL
      A0A8C6QVH0
      Conserved Domains (2) summary
      cd00060
      Location:132 → 240
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:252 → 525
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_029556673.1 → XP_029412533.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (2) summary
      cd00060
      Location:132 → 240
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl21453
      Location:252 → 459
      PKc_like; Protein Kinases, catalytic domain

    6. XM_029556670.1 → XP_029412530.1  serine/threonine-protein kinase Chk2 isoform X2

      UniProtKB/TrEMBL
      A0A8C6QVH0
      Conserved Domains (2) summary
      cd00060
      Location:132 → 240
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:252 → 525
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    RNA

    1. XR_003847165.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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