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    Kmt2d lysine methyltransferase 2D [ Nannospalax galili (Upper Galilee mountains blind mole rat) ]

    Gene ID: 103750570, updated on 11-Mar-2024

    Summary

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    Gene symbol
    Kmt2d
    Gene description
    lysine methyltransferase 2D
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nannospalax galili
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Spalacidae; Spalacinae; Nannospalax
    Orthologs
    human mouse all
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    Genomic context

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    See Kmt2d in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    102 current S.galili_v1.0 (GCF_000622305.1) Unplaced Scaffold NW_008355797.1 (723897..766564, complement)

    NW_008355797.1Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene formin-like protein 20 Neighboring gene RHEB like 1 Neighboring gene desert hedgehog signaling molecule

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_008355797 Unplaced Scaffold Reference S.galili_v1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns. Malik A, et al. PLoS One, 2011. PMID 21857902, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Nannospalax galili Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference S.galili_v1.0 Primary Assembly

    Genomic

    1. NW_008355797.1 Reference S.galili_v1.0 Primary Assembly

      Range
      723897..766564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_029556422.1 → XP_029412282.1  histone-lysine N-methyltransferase 2D isoform X3

      Conserved Domains (12) summary
      smart00398
      Location:2012 → 2063
      HMG; high mobility group
      smart00542
      Location:5206 → 5293
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2098 → 2524
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:227 → 272
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1417 → 1463
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1494 → 1544
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:133 → 216
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4998 → 5104
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4026 → 4325
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5147 → 5198
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5364 → 5518
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1366 → 1416
      PHD_SF; PHD finger superfamily

    2. XM_029556421.1 → XP_029412281.1  histone-lysine N-methyltransferase 2D isoform X2

      Conserved Domains (12) summary
      smart00398
      Location:2012 → 2063
      HMG; high mobility group
      smart00542
      Location:5206 → 5293
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2098 → 2524
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1417 → 1463
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1494 → 1544
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4998 → 5104
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4026 → 4325
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5147 → 5198
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5364 → 5518
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1366 → 1416
      PHD_SF; PHD finger superfamily

    3. XM_017803343.2 → XP_017658832.1  histone-lysine N-methyltransferase 2D isoform X7

      Conserved Domains (12) summary
      smart00398
      Location:2010 → 2061
      HMG; high mobility group
      smart00542
      Location:5204 → 5291
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2096 → 2522
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4996 → 5102
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4024 → 4323
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5145 → 5196
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5346 → 5500
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily

    4. XM_029556423.1 → XP_029412283.1  histone-lysine N-methyltransferase 2D isoform X4

      Conserved Domains (12) summary
      smart00398
      Location:2010 → 2061
      HMG; high mobility group
      smart00542
      Location:5204 → 5291
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2096 → 2522
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4996 → 5102
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4024 → 4323
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5145 → 5196
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5362 → 5516
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily

    5. XM_029556424.1 → XP_029412284.1  histone-lysine N-methyltransferase 2D isoform X5

      Conserved Domains (12) summary
      smart00398
      Location:2006 → 2057
      HMG; high mobility group
      smart00542
      Location:5200 → 5287
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2092 → 2518
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4992 → 5098
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4020 → 4319
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5141 → 5192
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5358 → 5512
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily

    6. XM_029556427.1 → XP_029412287.1  histone-lysine N-methyltransferase 2D isoform X9

      Conserved Domains (12) summary
      smart00398
      Location:2013 → 2064
      HMG; high mobility group
      smart00542
      Location:5184 → 5271
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2099 → 2525
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4976 → 5082
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4027 → 4326
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5125 → 5176
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5342 → 5496
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily

    7. XM_029556426.1 → XP_029412286.1  histone-lysine N-methyltransferase 2D isoform X8

      Conserved Domains (12) summary
      smart00398
      Location:2013 → 2064
      HMG; high mobility group
      smart00542
      Location:5185 → 5272
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2099 → 2525
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4977 → 5083
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4027 → 4326
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5126 → 5177
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5343 → 5497
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily

    8. XM_029556425.1 → XP_029412285.1  histone-lysine N-methyltransferase 2D isoform X6

      Conserved Domains (12) summary
      smart00398
      Location:2013 → 2064
      HMG; high mobility group
      smart00542
      Location:5207 → 5294
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2099 → 2525
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4999 → 5105
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4027 → 4326
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5148 → 5199
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5349 → 5503
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily

    9. XM_029556420.1 → XP_029412280.1  histone-lysine N-methyltransferase 2D isoform X1

      Conserved Domains (12) summary
      smart00398
      Location:2013 → 2064
      HMG; high mobility group
      smart00542
      Location:5207 → 5294
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:2099 → 2525
      PHA03247; large tegument protein UL36; Provisional
      cd15509
      Location:228 → 273
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15513
      Location:1418 → 1464
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15601
      Location:1495 → 1545
      PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
      cd15695
      Location:134 → 217
      ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
      cd15698
      Location:4999 → 5105
      ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
      pfam03154
      Location:4027 → 4326
      Atrophin-1; Atrophin-1 family
      pfam05964
      Location:5148 → 5199
      FYRN; F/Y-rich N-terminus
      cd19209
      Location:5365 → 5519
      SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
      cl22851
      Location:1367 → 1417
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version

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