Nppc natriuretic peptide C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nppcprovided by RGD
Official Full Name: natriuretic peptide Cprovided by RGD
Primary source: RGD:620850
See related: EnsemblRapid:ENSRNOG00000018854 AllianceGenome:RGD:620850
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in depressive disorder and hypertension. Orthologous to human NPPC (natriuretic peptide C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 25.0), Muscle (RPKM 18.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (94767986..94772186, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87320051..87324251, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (93731436..93735636, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans.
Title: C-type natriuretic peptide induces inotropic and lusitropic effects in human 3D-engineered cardiac tissue: Implications for the regulation of cardiac function in humans.
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors.
Title: CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors.
C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro.
Title: C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro.
CNP-KO rats might be a valuable animal model for investigating growth plate physiology and the mechanism of growth plate closure.
Title: Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats.
C-type Natriuretic Peptide Knock-out rats survive over one year, and exhibit a deficit in endochondral bone growth and growth retardation throughout life.
Title: Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.
Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats.
Title: Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B.
C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation.
Title: C-type natriuretic peptide and natriuretic peptide receptor B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia.
Title: Diagnostic value of plasma C-type natriuretic peptide levels in determination of the duration of mesenteric ischaemia.
The CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. Xiaoyaosan antagonizes this pathway at least partially.
Title: CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.
the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP.
Title: Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy.

Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

Nppc (e-PCR), detects polymorphism
- UniSTS:526953

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in c-di-GMP signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cGMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glycoprotein	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in cumulus cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in gastric emptying	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in growth plate cartilage chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal locomotion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of meiotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oocyte development	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mast cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of uterine smooth muscle relaxation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to oxygen-glucose deprivation	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-type natriuretic peptide

Names: natriuretic peptide precursor C; natriuretic peptide precursor type C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.