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    mahe maheshvara [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    maheprovided by FlyBase
    Official Full Name
    maheshvaraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029979
    Locus tag
    Dmel_CG10777
    See related
    AllianceGenome:FB:FBgn0029979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg10777; CG10777; dDDX5; dmDDX1; dmDDX17; Dmel\CG10777; dmMahe; DmRH1; Mahe
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; adult optic lobe; cuboidal/columnar epithelium; ganglia; and imaginal disc. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mahe in Genome Data Viewer
    Location:
    7C3-7C4; 1-21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7922158..7931382, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7816191..7825415, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene hold'em Neighboring gene YKT6 v-SNARE Neighboring gene Dehydrodolichyl diphosphate synthase subunit Neighboring gene Ribosomal protein S14a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function. Salpietro V, et al. Hum Mutat, 2018 Feb. PMID 29127725, Free PMC Article
    2. Regulation of Notch Signaling by an Evolutionary Conserved DEAD Box RNA Helicase, Maheshvara in Drosophila melanogaster. Surabhi S, et al. Genetics, 2015 Nov. PMID 26400611, Free PMC Article
    3. Maheshvara, a Conserved RNA Helicase, Regulates Notch Signaling in Drosophila melanogaster. Maurya B, et al. Adv Exp Med Biol, 2020. PMID 32072499
    4. Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex. Dutta D, et al. Adv Exp Med Biol, 2020. PMID 32072501
    5. Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster. Maurya B, et al. Cell Death Dis, 2021 Apr 6. PMID 33824299, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster.
      Title: Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster.
    2. REVIEW: Maheshvara, a Conserved RNA Helicase, Regulates Notch Signaling in Drosophila melanogaster
      Title: Maheshvara, a Conserved RNA Helicase, Regulates Notch Signaling in Drosophila melanogaster.
    3. mahe, which was originally designated as CG10777 in FlyBase, shows a dynamic pattern of expression and is expressed maternally and exhibits strong neuronal expression during embryogenesis and larval development
      Title: Regulation of Notch Signaling by an Evolutionary Conserved DEAD Box RNA Helicase, Maheshvara in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    maheshvara
    Names
    CG10777-PB
    CG10777-PC
    mahe-PB
    mahe-PC
    NP_001284994.1
    NP_572424.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7922158..7931382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132196.3 → NP_572424.1  maheshvara, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3M7
      Related
      FBpp0071084
      Conserved Domains (3) summary
      cd00079
      Location:457 → 594
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:239 → 446
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:136 → 656
      PTZ00110; helicase; Provisional

    2. NM_001298065.1 → NP_001284994.1  maheshvara, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3M7
      Conserved Domains (3) summary
      cd00079
      Location:457 → 594
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:239 → 446
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:136 → 656
      PTZ00110; helicase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3M7 Q9W3M7

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