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    Myl1 myosin, light polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 17901, updated on 27-Nov-2024

    Summary

    Official Symbol
    Myl1provided by MGI
    Official Full Name
    myosin, light polypeptide 1provided by MGI
    Primary source
    MGI:MGI:97269
    See related
    Ensembl:ENSMUSG00000061816 AllianceGenome:MGI:97269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mylf; MLC1f; MLC3f
    Summary
    Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in mammary gland adult (RPKM 118.5), limb E14.5 (RPKM 25.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myl1 in Genome Data Viewer
    Location:
    1 C3; 1 33.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66963454..66987091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66924295..66947932, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain Neighboring gene predicted gene, 27934 Neighboring gene predicted gene, 25832 Neighboring gene STARR-seq mESC enhancer starr_01192 Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene histidyl-tRNA synthetase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in contractile muscle fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in contractile muscle fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin light chain 1/3, skeletal muscle isoform
    Names
    A1 catalytic
    A2 catalytic
    MLC1/MLC3
    MLC1F/MLC3F
    myosin light chain A1/A2
    myosin light chain alkali 1/2
    myosin light chain, alkali, fast skeletal muscle
    myosin, light polypeptide 1, alkali; atrial, embryonic
    myosin, light polypeptide 4, alkali; atrial, embryonic

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113387.2NP_001106858.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

      See identical proteins and their annotated locations for NP_001106858.1

      Status: VALIDATED

      Source sequence(s)
      AC124389
      Consensus CDS
      CCDS48284.1
      UniProtKB/TrEMBL
      Q545G5, Q6PCW9
      Related
      ENSMUSP00000112861.2, ENSMUST00000119429.8
      Conserved Domains (1) summary
      PTZ00184
      Location:4149
      PTZ00184; calmodulin; Provisional
    2. NM_001420333.1NP_001407262.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

      Status: VALIDATED

      Source sequence(s)
      AC124389, AC133187
      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
    3. NM_001420334.1NP_001407263.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

      Status: VALIDATED

      Source sequence(s)
      AC124389
      UniProtKB/TrEMBL
      Q545G5
    4. NM_021285.4NP_067260.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

      See identical proteins and their annotated locations for NP_067260.1

      Status: VALIDATED

      Source sequence(s)
      AC124389, AC133187
      Consensus CDS
      CCDS15024.1
      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
      Related
      ENSMUSP00000027151.6, ENSMUST00000027151.12
      Conserved Domains (1) summary
      PTZ00184
      Location:39187
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      66963454..66987091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162616.1XP_036018509.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
      Conserved Domains (1) summary
      PTZ00184
      Location:39187
      PTZ00184; calmodulin; Provisional
    2. XM_036162618.1XP_036018511.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
      Conserved Domains (1) summary
      PTZ00184
      Location:39187
      PTZ00184; calmodulin; Provisional
    3. XM_011238451.4XP_011236753.1  myosin light chain 1/3, skeletal muscle isoform isoform X2

      UniProtKB/TrEMBL
      E9PWG4, Q6PCW9
      Related
      ENSMUSP00000112880.2, ENSMUST00000120415.8
      Conserved Domains (1) summary
      PTZ00184
      Location:4141
      PTZ00184; calmodulin; Provisional