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    otp orthopedia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    otpprovided by FlyBase
    Official Full Name
    orthopediaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015524
    Locus tag
    Dmel_CG10036
    See related
    AllianceGenome:FB:FBgn0015524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE58095; bk24; CG10036; CG2965; Dmel\CG10036; Otp; w26; W26
    Summary
    Enables DNA binding activity. Predicted to be involved in neuron differentiation. Is expressed in several structures, including anal pad; central brain primordium; embryonic brain; gut section; and ventral nerve cord. Orthologous to human OTP (orthopedia homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See otp in Genome Data Viewer
    Location:
    57B4-57B4; 2-92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20883625..20903414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16771130..16790919, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Inositol phosphate kinase 1 Neighboring gene Calcium and integrin binding family member 2 Neighboring gene antisense RNA:CR43160 Neighboring gene Carbonic anhydrase 15 Neighboring gene Retinal Homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Otx and Otp genes in brain development. Acampora D, et al. Int J Dev Biol, 2000. PMID 11061431
    2. When Brachyury meets Smad1: the evolution of bilateral symmetry during gastrulation. Marcellini S. Bioessays, 2006 Apr. PMID 16547957
    3. Orthopedia expression during Drosophila melanogaster nervous system development and its regulation by microRNA-252. Hildebrandt K, et al. Dev Biol, 2022 Dec. PMID 36179878
    4. The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut. Hildebrandt K, et al. Hereditas, 2020 Nov 19. PMID 33213520, Free PMC Article
    5. Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development. Eggert T, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482887, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brachyenteron activates the homeobox gene orthopedia.
      Title: Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    orthopedia
    Names
    CG10036-PC
    CG10036-PE
    CG10036-PF
    CG10036-PG
    CG10036-PH
    CG10036-PI
    CG10036-PJ
    CG10036-PK
    CG10036-PL
    otp-PC
    otp-PE
    otp-PF
    otp-PG
    otp-PH
    otp-PI
    otp-PJ
    otp-PK
    otp-PL

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20883625..20903414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001369956.1 → NP_001356966.1  orthopedia, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4P7VNY3
      Conserved Domains (1) summary
      pfam00046
      Location:112 → 161
      Homeobox; Homeobox domain

    2. NM_001299723.1 → NP_001286652.1  orthopedia, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG13
      Conserved Domains (1) summary
      pfam00046
      Location:112 → 160
      Homeobox; Homeobox domain

    3. NM_001103918.3 → NP_001097388.2  orthopedia, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097388.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ64, P56672, Q3KN52, Q7KVQ3, Q9W2Q4
      Conserved Domains (1) summary
      pfam00046
      Location:112 → 160
      Homeobox; Homeobox domain

    4. NM_001299724.1 → NP_001286653.1  orthopedia, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG58
      Conserved Domains (1) summary
      pfam00046
      Location:119 → 167
      Homeobox; Homeobox domain

    5. NM_001299725.1 → NP_001286654.1  orthopedia, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH19
      Conserved Domains (1) summary
      pfam00046
      Location:119 → 167
      Homeobox; Homeobox domain

    6. NM_079075.5 → NP_523799.3  orthopedia, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523799.3

      Status: REVIEWED

      Related
      FBpp0309633
      Conserved Domains (1) summary
      pfam00046
      Location:9 → 57
      Homeobox; Homeobox domain

    7. NM_001299722.1 → NP_001286651.1  orthopedia, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFU7
      Conserved Domains (1) summary
      pfam00046
      Location:9 → 57
      Homeobox; Homeobox domain

    8. NM_001043098.2 → NP_001036563.1  orthopedia, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P56672
      Conserved Domains (1) summary
      pfam00046
      Location:16 → 64
      Homeobox; Homeobox domain

    9. NM_001299721.1 → NP_001286650.1  orthopedia, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286650.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFZ2
      Conserved Domains (1) summary
      pfam00046
      Location:16 → 65
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFU7 A0A0B4LFU7
    A0A0B4LFZ2 A0A0B4LFZ2
    A0A0B4LG13 A0A0B4LG13
    A0A0B4LG58 A0A0B4LG58
    A0A0B4LH19 A0A0B4LH19
    A0A4P7VNY3 A0A4P7VNY3
    P56672.2 P56672
    Q8SYH5 Q8SYH5

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