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    AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 56894, updated on 9-Dec-2024

    Summary

    Official Symbol
    AGPAT3provided by HGNC
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:326
    See related
    Ensembl:ENSG00000160216 MIM:614794; AllianceGenome:HGNC:326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPAAT3; LPLAT3; 1-AGPAT 3; LPAAT-GAMMA1
    Summary
    The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 12.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AGPAT3 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43865223..43987592)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42220581..42343213)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45285104..45407473)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905033 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45269891-45270437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18552 Neighboring gene CRISPRi-validated cis-regulatory element chr21.1179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13373 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45299777-45299961 Neighboring gene MYL6 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45302099-45302685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45305625-45306210 Neighboring gene uncharacterized LOC124905034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45328253-45328754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45336568-45337118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45337119-45337668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45339493-45340392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45340393-45341290 Neighboring gene Sharpr-MPRA regulatory region 2423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45342191-45343088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45344887-45345786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45345787-45346684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45351938-45352438 Neighboring gene RNA, U6 small nuclear 859, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45354036-45354854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45358304-45359204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45359205-45360103 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45360643-45360814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45363715-45364558 Neighboring gene uncharacterized LOC105372826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45376043-45376543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45401087-45401848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45401849-45402610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45402611-45403372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45405825-45406355 Neighboring gene uncharacterized LOC105372829 Neighboring gene RNA, U6 small nuclear 1150, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18561 Neighboring gene trafficking protein particle complex subunit 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45452244-45452456 Neighboring gene H2A.Z histone pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4604

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in phospholipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
    Names
    1-AGP acyltransferase 3
    lysophosphatidic acid acyltransferase gamma
    lysophosphatidic acid acyltransferase-gamma1
    lysophospholipid acyltransferase 3
    NP_001032642.1
    NP_001356807.1
    NP_001356809.1
    NP_001356810.1
    NP_064517.1
    XP_005261217.1
    XP_006724093.1
    XP_006724094.1
    XP_011527963.2
    XP_011527965.2
    XP_016883897.1
    XP_016883900.1
    XP_047296870.1
    XP_047296871.1
    XP_047296872.1
    XP_047296873.1
    XP_047296874.1
    XP_047296875.1
    XP_047296876.1
    XP_047296877.1
    XP_047296878.1
    XP_047296879.1
    XP_047296880.1
    XP_047296881.1
    XP_047296882.1
    XP_047296883.1
    XP_047296884.1
    XP_047296885.1
    XP_054180677.1
    XP_054180678.1
    XP_054180679.1
    XP_054180680.1
    XP_054180681.1
    XP_054180682.1
    XP_054180683.1
    XP_054180684.1
    XP_054180685.1
    XP_054180686.1
    XP_054180687.1
    XP_054180688.1
    XP_054180689.1
    XP_054180690.1
    XP_054180691.1
    XP_054180692.1
    XP_054180693.1
    XP_054180694.1
    XP_054180695.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037553.2NP_001032642.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

      See identical proteins and their annotated locations for NP_001032642.1

      Status: REVIEWED

      Source sequence(s)
      AB001523, AP001054
      Consensus CDS
      CCDS13703.1
      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Related
      ENSP00000381140.2, ENST00000398063.6
      Conserved Domains (1) summary
      PLN02380
      Location:17325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    2. NM_001369878.1NP_001356807.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB001523, AP001053, AP001054
      Consensus CDS
      CCDS13703.1
      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Conserved Domains (1) summary
      PLN02380
      Location:17325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    3. NM_001369880.1NP_001356809.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

      Status: REVIEWED

      Source sequence(s)
      AB001523, AP001054
      Consensus CDS
      CCDS13703.1
      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Conserved Domains (1) summary
      PLN02380
      Location:17325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    4. NM_001369881.1NP_001356810.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB001523, AP001053, AP001054
      Conserved Domains (2) summary
      cd07990
      Location:1194
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:181252
      Acyltransf_C; Acyltransferase C-terminus
    5. NM_020132.5NP_064517.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

      See identical proteins and their annotated locations for NP_064517.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AB001523, AP001053, AP001054, BC063552, CD672915
      Consensus CDS
      CCDS13703.1
      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Related
      ENSP00000291572.8, ENST00000291572.13
      Conserved Domains (1) summary
      PLN02380
      Location:17325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      43865223..43987592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440922.1XP_047296878.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    2. XM_047440916.1XP_047296872.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    3. XM_047440921.1XP_047296877.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    4. XM_047440915.1XP_047296871.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    5. XM_047440923.1XP_047296879.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    6. XM_006724031.4XP_006724094.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

      See identical proteins and their annotated locations for XP_006724094.1

      UniProtKB/Swiss-Prot
      Q9NRZ7
      Conserved Domains (2) summary
      cd07990
      Location:1194
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:181252
      Acyltransf_C; Acyltransferase C-terminus
    7. XM_047440926.1XP_047296882.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    8. XM_005261160.5XP_005261217.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      See identical proteins and their annotated locations for XP_005261217.1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Related
      ENSP00000381138.1, ENST00000398061.5
      Conserved Domains (1) summary
      PLN02380
      Location:17325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    9. XM_047440924.1XP_047296880.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    10. XM_047440925.1XP_047296881.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    11. XM_017028408.2XP_016883897.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X7

    12. XM_047440920.1XP_047296876.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X5

    13. XM_047440928.1XP_047296884.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    14. XM_011529663.3XP_011527965.2  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    15. XM_047440917.1XP_047296873.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X3

    16. XM_047440918.1XP_047296874.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X4

    17. XM_047440914.1XP_047296870.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    18. XM_047440919.1XP_047296875.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Related
      ENSP00000381135.1, ENST00000398058.5
    19. XM_047440929.1XP_047296885.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    20. XM_047440927.1XP_047296883.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    21. XM_006724030.4XP_006724093.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      See identical proteins and their annotated locations for XP_006724093.1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
      Conserved Domains (1) summary
      PLN02380
      Location:17325
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    22. XM_011529661.3XP_011527963.2  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    23. XM_017028411.2XP_016883900.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

      UniProtKB/Swiss-Prot
      Q9NRZ7
      Conserved Domains (2) summary
      cd07990
      Location:1194
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:181252
      Acyltransf_C; Acyltransferase C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      42220581..42343213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324710.1XP_054180685.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    2. XM_054324703.1XP_054180678.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    3. XM_054324709.1XP_054180684.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    4. XM_054324702.1XP_054180677.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    5. XM_054324711.1XP_054180686.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    6. XM_054324717.1XP_054180692.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    7. XM_054324712.1XP_054180687.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    8. XM_054324713.1XP_054180688.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    9. XM_054324714.1XP_054180689.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    10. XM_054324708.1XP_054180683.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X7

    11. XM_054324705.1XP_054180680.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X5

    12. XM_054324718.1XP_054180693.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    13. XM_054324707.1XP_054180682.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    14. XM_054324704.1XP_054180679.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X3

    15. XM_054324720.1XP_054180695.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X10

    16. XM_054324719.1XP_054180694.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X9

    17. XM_054324706.1XP_054180681.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    18. XM_054324715.1XP_054180690.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

      UniProtKB/Swiss-Prot
      D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    19. XM_054324716.1XP_054180691.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6