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    Jon74E Jonah 74E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon74Eprovided by FlyBase
    Official Full Name
    Jonah 74Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023197
    Locus tag
    Dmel_CG6298
    See related
    AllianceGenome:FB:FBgn0023197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6298; CT19724; Dmel\CG6298; SP85
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon74E in Genome Data Viewer
    Location:
    74D3-74D4; 3-45 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17548077..17549127, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17539839..17542227, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Enhancer of decapping 3 Neighboring gene long non-coding RNA:CR45165 Neighboring gene Nedd4 Neighboring gene uncharacterized protein Neighboring gene Cyclin T

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins. Burtis KC, et al. Cell, 1990 Apr 6. PMID 2107982
    2. Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo. Keleman K, et al. Nat Neurosci, 2005 Feb. PMID 15657595
    3. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610
    4. Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure. Rollmann SM, et al. Genetics, 2008 Jul. PMID 18562639, Free PMC Article
    5. Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging. Jiao J, et al. Cell Rep, 2023 Jan 31. PMID 36640359, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 74E
    Names
    CG6298-PC
    Jon74E-PC
    NP_001189126.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17548077..17549127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202197.1 → NP_001189126.2  jonah 74E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP19, M9MS20
      Conserved Domains (1) summary
      smart00020
      Location:31 → 262
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MS20 M9MS20

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