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    nvd neverland [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nvdprovided by FlyBase
    Official Full Name
    neverlandprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287185
    Locus tag
    Dmel_CG40050
    See related
    AllianceGenome:FB:FBgn0287185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    80Fc; CG40050; Dmel\CG40050; l(3)80Fc; l(3)Lh6; l6; Nvd; NVD; nvd-Dm
    Summary
    Enables cholesterol 7-desaturase (NAD(P)H) activity. Involved in ecdysteroid biosynthetic process; instar larval development; and metamorphosis. Predicted to be active in cytoplasm. Is expressed in follicle cell; germline cyst; nurse cell; prothoracic gland; and ring gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nvd in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (24324866..24401655)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (24317966..24394755)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Synaptosomal-associated protein 25kDa Neighboring gene long non-coding RNA:CR45159 Neighboring gene pseudo Neighboring gene mitochondrial ribosomal protein S5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Soluble expression, purification and biochemical characterization of a C-7 cholesterol dehydrogenase from Drosophila melanogaster. Zhu Z, et al. Steroids, 2019 Dec. PMID 31521708
    2. Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development in Drosophila. Enya S, et al. Genetics, 2017 Dec. PMID 29021278, Free PMC Article
    3. Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species. Lang M, et al. Science, 2012 Sep 28. PMID 23019649, Free PMC Article
    4. Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth. Yoshiyama T, et al. Development, 2006 Jul. PMID 16763204
    5. Characterization of candidate intermediates in the Black Box of the ecdysone biosynthetic pathway in Drosophila melanogaster: Evaluation of molting activities on ecdysteroid-defective larvae. Saito J, et al. J Insect Physiol, 2016 Oct-Nov. PMID 27662806

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The neverland (nvd) gene encodes an oxygenase-like protein with a Rieske electron carrier domain, from the silkworm Bombyx mori and the fruitfly Drosophila melanogaster
      Title: Neverland is an evolutionally conserved Rieske-domain protein that is essential for ecdysone synthesis and insect growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    mobile_element

    • Loc: 24369119-24372918 mobile_element_type = transposon:Doc{}6512
    • Loc: 24376573-24377682 mobile_element_type = transposon:1360{}6364

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholesterol 7-desaturase (NAD(P)H) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ecdysteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metamorphosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neverland
    Names
    CG40050-PA
    lethal (3) 80Fc
    lethal 6
    lethal6
    nvd-PA
    NP_001097670.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      24324866..24401655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104200.3 → NP_001097670.1  neverland [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1JUZ1, Q5BIG3
      Conserved Domains (1) summary
      cd03469
      Location:97 → 210
      Rieske_RO_Alpha_N; Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1JUZ1.1 Q1JUZ1

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