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    Epp Ecdysteroid phosphate phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eppprovided by FlyBase
    Official Full Name
    Ecdysteroid phosphate phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039137
    Locus tag
    Dmel_CG13604
    See related
    AllianceGenome:FB:FBgn0039137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13604; Dmel\CG13604; EPP; UBASH3A
    Summary
    Enables acid phosphatase activity and ecdysteroid-phosphate phosphatase activity. Involved in ecdysteroid metabolic process. Located in cytosol and nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to several human genes including UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Epp in Genome Data Viewer
    Location:
    95D5-95D5; 3-82 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23988806..23992916, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19814528..19818638, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab7 Neighboring gene uncharacterized protein Neighboring gene Like Sm 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An unsuspected ecdysteroid/steroid phosphatase activity in the key T-cell regulator, Sts-1: surprising relationship to insect ecdysteroid phosphate phosphatase. Davies L, et al. Proteins, 2007 May 15. PMID 17348005
    2. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article
    3. Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. Mazumder R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466548, Free PMC Article
    4. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article
    5. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ecdysteroid-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysteroid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ecdysteroid phosphate phosphatase
    Names
    CG13604-PA
    CG13604-PB
    CG13604-PC
    CG13604-PD
    CG13604-PE
    Epp-PA
    Epp-PB
    Epp-PC
    Epp-PD
    Epp-PE
    NP_001097896.1
    NP_001097897.1
    NP_001097898.1
    NP_001262894.1
    NP_651202.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23988806..23992916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104428.1 → NP_001097898.1  ecdysteroid phosphate phosphatase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR97
      Conserved Domains (3) summary
      cd11791
      Location:241 → 299
      SH3_UBASH3; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing proteins, also called TULA (T cell Ubiquitin LigAnd) family of proteins
      cd14301
      Location:23 → 60
      UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins
      pfam00300
      Location:460 → 694
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    2. NM_142945.3 → NP_651202.1  ecdysteroid phosphate phosphatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86PB2, Q9VCE9
      Related
      FBpp0083896
      Conserved Domains (3) summary
      cd11791
      Location:275 → 333
      SH3_UBASH3; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing proteins, also called TULA (T cell Ubiquitin LigAnd) family of proteins
      cd14301
      Location:23 → 60
      UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins
      pfam00300
      Location:494 → 728
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    3. NM_001275965.1 → NP_001262894.1  ecdysteroid phosphate phosphatase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHR3
      Conserved Domains (3) summary
      cd11791
      Location:275 → 333
      SH3_UBASH3; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing proteins, also called TULA (T cell Ubiquitin LigAnd) family of proteins
      cd14301
      Location:23 → 60
      UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins
      pfam00300
      Location:494 → 728
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    4. NM_001104426.1 → NP_001097896.1  ecdysteroid phosphate phosphatase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PB2
      Conserved Domains (1) summary
      pfam00300
      Location:55 → 289
      His_Phos_1; Histidine phosphatase superfamily (branch 1)

    5. NM_001104427.1 → NP_001097897.1  ecdysteroid phosphate phosphatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PB2
      Conserved Domains (1) summary
      pfam00300
      Location:55 → 289
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHR3 A0A0B4KHR3
    A8JR97 A8JR97
    Q9VCE9.1 Q9VCE9

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