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    snk snake [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snkprovided by FlyBase
    Official Full Name
    snakeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003450
    Locus tag
    Dmel_CG7996
    See related
    AllianceGenome:FB:FBgn0003450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP26; CG7996; cSP26; Dmel\CG7996; l(3)87Dg; me(3)4; Snk; SNK; SP26
    Summary
    Enables serine-type endopeptidase activity. Involved in Toll receptor ligand protein activation cascade; dorsal/ventral axis specification; and zymogen activation. Predicted to be active in extracellular space. Is expressed in egg chamber and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See snk in Genome Data Viewer
    Location:
    87D9-87D9; 3-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13040165..13042770, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8865887..8868492, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) 87Df Neighboring gene rosy Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 cognate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial regulation of Drosophila snake protease activity in the generation of dorsal-ventral polarity. Smith CL, et al. Development, 1995 Dec. PMID 8575313
    2. A common domain within the proenzyme regions of the Drosophila snake and easter proteins and Tachypleus proclotting enzyme defines a new subfamily of serine proteases. Smith CL, et al. Protein Sci, 1992 Sep. PMID 1304399, Free PMC Article
    3. Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain. Smith C, et al. Genetics, 1994 Apr. PMID 8013912, Free PMC Article
    4. Mutagenesis of the cysteine-rich clip domain in the Drosophila patterning protease, Snake. Tian S, et al. Arch Biochem Biophys, 2008 Jul 15. PMID 18477463, Free PMC Article
    5. Gastrulation defective protease interacts with anionic components of the Drosophila ovary extracellular matrix. Sukumari-Ramesh S, et al. Protein Pept Lett, 2009. PMID 19356143, Free PMC Article

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. observation suggests a mechanism in which the sulfated target of Pipe promotes a productive interaction between Snake and Easter, perhaps by facilitating conformational changes in a complex containing the two proteins
      Title: Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.
    2. Snake activation is cascade-dependent but pipe-independent. Snake's activation of Easter is the first spatially regulated step in the dorsoventral protease cascade.
      Title: Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.
    3. Mutagenesis of the cysteine-rich clip domain in the Drosophila patterning protease, Snake, is reported.
      Title: Mutagenesis of the cysteine-rich clip domain in the Drosophila patterning protease, Snake.
    4. provision of three-dimensional model and role of cation binding sites in embryo patterning
      Title: Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in zymogen activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    snake
    Names
    CG7996-PA
    CG7996-PB
    CG7996-PC
    snk-PA
    snk-PB
    snk-PC
    NP_001097766.1
    NP_001262525.1
    NP_524338.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13040165..13042770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104296.2 → NP_001097766.1  snake, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05049, Q29QH0, Q9VFZ7
      UniProtKB/TrEMBL
      A8JQZ2
      Conserved Domains (3) summary
      smart00680
      Location:93 → 139
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:186 → 427
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:186 → 430
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001275596.1 → NP_001262525.1  snake, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGH9
      Conserved Domains (2) summary
      smart00680
      Location:93 → 139
      CLIP; Clip or disulphide knot domain
      cl21584
      Location:186 → 249
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_079614.3 → NP_524338.2  snake, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524338.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05049, Q29QH0, Q9VFZ7
      UniProtKB/TrEMBL
      A8JQZ2
      Related
      FBpp0082184
      Conserved Domains (3) summary
      smart00680
      Location:93 → 139
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:186 → 427
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:186 → 430
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGH9 A0A0B4KGH9
    A8JQZ2 A8JQZ2
    P05049.2 P05049

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