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    Nxt1 NTF2-related export protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 56488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nxt1provided by MGI
    Official Full Name
    NTF2-related export protein 1provided by MGI
    Primary source
    MGI:MGI:1929619
    See related
    Ensembl:ENSMUSG00000036992 AllianceGenome:MGI:1929619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110001N02Rik
    Summary
    Enables small GTPase binding activity. Acts upstream of or within RNA export from nucleus and protein export from nucleus. Part of nuclear pore. Is expressed in several structures, including central nervous system; gut; sensory organ; submandibular gland primordium; and tail dorsal root ganglion. Orthologous to human NXT1 (nuclear transport factor 2 like export factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 59.4), CNS E11.5 (RPKM 25.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nxt1 in Genome Data Viewer
    Location:
    2 G3; 2 73.53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148514535..148517946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148672615..148676026)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05971 Neighboring gene predicted gene, 46770 Neighboring gene STARR-seq mESC enhancer starr_05973 Neighboring gene predicted gene, 25866 Neighboring gene STARR-positive B cell enhancer ABC_E2052 Neighboring gene STARR-positive B cell enhancer mm9_chr2:148506639-148506940 Neighboring gene predicted gene, 46771 Neighboring gene GDNF-inducible zinc finger protein 1 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein beta Neighboring gene predicted gene, 54122

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents. Hu J, et al. Zoology (Jena), 2022 Apr. PMID 35219094
    2. RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex. Lévesque L, et al. J Biol Chem, 2001 Nov 30. PMID 11579093
    3. Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element. Skinner SJ, et al. J Biol Chem, 2008 Feb 8. PMID 18048358
    4. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. Black BE, et al. Mol Cell Biol, 1999 Dec. PMID 10567585, Free PMC Article
    5. Molecular cloning and functional characterization of mouse Nxf family gene products. Sasaki M, et al. Genomics, 2005 May. PMID 15820316

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
      Title: Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents.
    2. regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport by ERK map kinases requires TAP-NxT1 binding and the AU-rich element
      Title: Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear RNA export factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear RNA export factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NTF2-related export protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110159.1 → NP_001103629.1  NTF2-related export protein 1

      See identical proteins and their annotated locations for NP_001103629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL928638, AW908959, BY091455, CJ186513
      Consensus CDS
      CCDS16840.1
      UniProtKB/Swiss-Prot
      Q3THE3, Q9D1P7, Q9QZV9
      Related
      ENSMUSP00000105587.2, ENSMUST00000109961.8
      Conserved Domains (1) summary
      cd00780
      Location:12 → 137
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. NM_019761.6 → NP_062735.4  NTF2-related export protein 1

      See identical proteins and their annotated locations for NP_062735.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK003254, AL928638, AW908959, CJ186513
      Consensus CDS
      CCDS16840.1
      UniProtKB/Swiss-Prot
      Q3THE3, Q9D1P7, Q9QZV9
      Related
      ENSMUSP00000038329.4, ENSMUST00000047177.4
      Conserved Domains (1) summary
      cd00780
      Location:12 → 137
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      148514535..148517946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZV9.2 GenPept UniProtKB/Swiss-Prot:Q9QZV9

    Gene LinkOut

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