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    Rbmxl1 Rbmx like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbmxl1provided by RGD
    Official Full Name
    Rbmx like 1provided by RGD
    Primary source
    RGD:1306751
    See related
    EnsemblRapid:ENSRNOG00000062375 AllianceGenome:RGD:1306751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rbmx; Rbmxrt; Rbmxrtl
    Summary
    Enables RNA binding activity. Involved in protein-containing complex assembly and regulation of mRNA splicing, via spliceosome. Part of supraspliceosomal complex. Orthologous to human RBMXL1 (RBMX like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 228.6), Spleen (RPKM 183.6) and 9 other tissues See more
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    Genomic context

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    See Rbmxl1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (46312176..46315802)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (29407902..29411519)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (33081473..33084988)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene reeler domain containing 1 Neighboring gene solute carrier family 10, member 7 Neighboring gene large ribosomal subunit protein eL28-like Neighboring gene 60S ribosomal protein L21-like Neighboring gene POU class 4 homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. Takemoto T, et al. FEBS Lett, 2007 Jan 23. PMID 17188681
    2. SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene. Omura Y, et al. BMB Rep, 2009 Apr 30. PMID 19403048
    3. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. Heinrich B, et al. J Biol Chem, 2009 May 22. PMID 19282290, Free PMC Article
    4. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. Wang J, et al. J Neurochem, 2004 Mar. PMID 15009664
    5. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Misawa K, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10716735, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-1 ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of supraspliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding motif protein, X chromosome retrogene-like
    Names
    RNA binding motif protein, X chromosome retrogene
    RNA binding motif protein, X chromosome retrogene-like
    RNA binding motif protein, X-linked-like 1
    heterogeneous nuclear ribonucleoprotein G retrogene-like
    hnRNP G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107420.1 → NP_001100890.1  RNA-binding motif protein, X chromosome retrogene-like

      See identical proteins and their annotated locations for NP_001100890.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/Swiss-Prot
      P84586
      UniProtKB/TrEMBL
      A0A8I6AKQ4, A6IYJ5
      Conserved Domains (3) summary
      COG0724
      Location:1 → 85
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      46312176..46315802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097729.2 → XP_038953657.1  RNA-binding motif protein, X chromosome retrogene-like isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN66, A0A8I6AKQ4
      Related
      ENSRNOP00000100651.1, ENSRNOT00000129732.1
      Conserved Domains (3) summary
      PRK14086
      Location:162 → 303
      dnaA; chromosomal replication initiator protein DnaA
      pfam08081
      Location:170 → 214
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 86
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    2. XM_063278022.1 → XP_063134092.1  RNA-binding motif protein, X chromosome retrogene-like isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84586.1 GenPept UniProtKB/Swiss-Prot:P84586

    Gene LinkOut

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