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    Thoc3 THO complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290519, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Thoc3provided by RGD
    Official Full Name
    THO complex subunit 3provided by RGD
    Primary source
    RGD:1311669
    See related
    EnsemblRapid:ENSRNOG00000000104 AllianceGenome:RGD:1311669
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mRNA export from nucleus. Predicted to be located in chromosome, telomeric region. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC3 (THO complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 171.9), Adrenal (RPKM 116.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thoc3 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (10148281..10157472)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (10143184..10152375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10676943..10686134)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482678 Neighboring gene uncharacterized LOC134482679 Neighboring gene MAPK regulated co-repressor interacting protein 1 like 1 Neighboring gene uncharacterized LOC120097924 Neighboring gene long non-coding RNA 012 Neighboring gene complexin 2 Neighboring gene uncharacterized LOC134482680

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Chi B, et al. Nucleic Acids Res, 2013 Jan. PMID 23222130, Free PMC Article
    2. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825
    3. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. Boyne JR, et al. PLoS Pathog, 2008 Oct. PMID 18974867, Free PMC Article
    4. Human mRNA export machinery recruited to the 5' end of mRNA. Cheng H, et al. Cell, 2006 Dec 29. PMID 17190602
    5. Recruitment of the human TREX complex to mRNA during splicing. Masuda S, et al. Genes Dev, 2005 Jul 1. PMID 15998806, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 3
    Names
    THO complex 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106059.1 → NP_001099529.1  THO complex subunit 3

      See identical proteins and their annotated locations for NP_001099529.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474032
      UniProtKB/TrEMBL
      A6KB01, B5DEY5, F7EUM8
      Related
      ENSRNOP00000000116.6, ENSRNOT00000000116.7
      Conserved Domains (2) summary
      cd00200
      Location:49 → 290
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:59 → 97
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      10148281..10157472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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