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    Cgnl1 cingulin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315795, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cgnl1provided by RGD
    Official Full Name
    cingulin-like 1provided by RGD
    Primary source
    RGD:1304623
    See related
    EnsemblRapid:ENSRNOG00000054080 AllianceGenome:RGD:1304623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304623
    Summary
    Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; negative regulation of stress fiber assembly; and protein localization to cell-cell junction. Predicted to be located in actin cytoskeleton and apical junction complex. Predicted to be part of protein-containing complex. Predicted to be active in bicellular tight junction. Orthologous to human CGNL1 (cingulin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 795.7), Adrenal (RPKM 182.5) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Cgnl1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (81154169..81305598, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (72273401..72424842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (78126670..78278490, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094203 Neighboring gene myocardial zonula adherens protein Neighboring gene dynein light chain LC8-type 1, pseudogene 1 Neighboring gene uncharacterized LOC134480205 Neighboring gene transcription factor 12 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108164.2NP_001101634.1  cingulin-like protein 1

      See identical proteins and their annotated locations for NP_001101634.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Related
      ENSRNOP00000106701.1, ENSRNOT00000131419.1
      Conserved Domains (1) summary
      pfam01576
      Location:6171248
      Myosin_tail_1; Myosin tail
    2. NM_001389277.1NP_001376206.1  cingulin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Related
      ENSRNOP00000103389.1, ENSRNOT00000165694.1
      Conserved Domains (1) summary
      pfam01576
      Location:6171248
      Myosin_tail_1; Myosin tail

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      81154169..81305598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766286.4XP_008764508.1  cingulin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008764508.1

      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Conserved Domains (1) summary
      pfam01576
      Location:6171248
      Myosin_tail_1; Myosin tail
    2. XM_039081510.2XP_038937438.1  cingulin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMD9, A6KEQ6, D4A3V5
      Conserved Domains (1) summary
      pfam01576
      Location:6171248
      Myosin_tail_1; Myosin tail
    3. XM_039081511.2XP_038937439.1  cingulin-like protein 1 isoform X2

      Conserved Domains (1) summary
      pfam01576
      Location:139697
      Myosin_tail_1; Myosin tail