U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Sesn3 sestrin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315427, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sesn3provided by RGD
    Official Full Name
    sestrin 3provided by RGD
    Primary source
    RGD:1309470
    See related
    EnsemblRapid:ENSRNOG00000008173 AllianceGenome:RGD:1309470
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Predicted to be involved in several processes, including TORC2 signaling; cellular response to L-leucine; and regulation of signal transduction. Predicted to act upstream of or within glucose homeostasis; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to insulin. Predicted to be located in cytoplasm. Predicted to be part of GATOR2 complex and TORC2 complex. Orthologous to human SESN3 (sestrin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 392.0), Thymus (RPKM 305.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sesn3 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (19415307..19470943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (11133822..11189436)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (12823060..12878749)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480141 Neighboring gene uncharacterized LOC134480142 Neighboring gene uncharacterized LOC103693014 Neighboring gene uncharacterized LOC120094081 Neighboring gene endonuclease domain containing 1 Neighboring gene lysine (K)-specific demethylase 4D-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-leucine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxidoreductase activity, acting on peroxide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to L-leucine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to leucine starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108125.1NP_001101595.1  sestrin-3

      See identical proteins and their annotated locations for NP_001101595.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473993
      UniProtKB/TrEMBL
      A6JN85, D4A469
      Related
      ENSRNOP00000112076.1, ENSRNOT00000124821.1
      Conserved Domains (1) summary
      pfam04636
      Location:39490
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      19415307..19470943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265329.1XP_063121399.1  sestrin-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0N4, D4A469
      Related
      ENSRNOP00000084144.1, ENSRNOT00000107936.2