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    Rpl27a ribosomal protein L27A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpl27aprovided by RGD
    Official Full Name
    ribosomal protein L27Aprovided by RGD
    Primary source
    RGD:1309771
    See related
    EnsemblRapid:ENSRNOG00000088362 AllianceGenome:RGD:1309771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPL27A (ribosomal protein L27a). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 3458.8), Thymus (RPKM 3017.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl27a in Genome Data Viewer
    Location:
    1q33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172971957..172977591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (163539732..163542771)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174132798..174135816)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 33 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134483770 Neighboring gene tripartite motif-containing 66 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene small nucleolar RNA, H/ACA box 3B Neighboring gene DENN domain containing 2B Neighboring gene uncharacterized LOC134483772 Neighboring gene charged multivesicular body protein 1b-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. Fleming G, et al. Proc Natl Acad Sci U S A, 1989 Jan. PMID 2643099, Free PMC Article
    2. The primary structure of rat ribosomal proteins: the amino acid sequences of L27a and L28 and corrections in the sequences of S4 and S12. Wool IG, et al. Biochim Biophys Acta, 1990 Aug 27. PMID 2207170
    3. Isolation of eukaryotic ribosomal proteins. Purification and characterization of 60 S ribosomal subunit proteins L3, L6, L7', L8, L10, L15, L17, L18, L19, L23', L25, L27', L28, L29, L31, L32, L34, L35, L36, L36', and L37'. Tsurugi K, et al. J Biol Chem, 1977 Jun 10. PMID 863909
    4. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. Odintsova TI, et al. J Protein Chem, 2003 Apr. PMID 12962325
    5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL15
    Names
    60S ribosomal protein L27a
    NP_001099760.1
    XP_038962893.1
    XP_063141882.1
    XP_063141886.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106290.1 → NP_001099760.1  large ribosomal subunit protein uL15

      See identical proteins and their annotated locations for NP_001099760.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/Swiss-Prot
      P18445
      UniProtKB/TrEMBL
      A6I7W7
      Conserved Domains (1) summary
      PTZ00160
      Location:1 → 148
      PTZ00160; 60S ribosomal protein L27a; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      172971957..172977591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285816.1 → XP_063141886.1  large ribosomal subunit protein uL15 isoform X1

      UniProtKB/Swiss-Prot
      P18445
      UniProtKB/TrEMBL
      A6I7W7
      Related
      ENSRNOP00000104380.1, ENSRNOT00000145523.1

    2. XM_063285812.1 → XP_063141882.1  large ribosomal subunit protein uL15 isoform X1

      UniProtKB/Swiss-Prot
      P18445
      UniProtKB/TrEMBL
      A6I7W7

    3. XM_039106965.2 → XP_038962893.1  large ribosomal subunit protein uL15 isoform X2

      UniProtKB/TrEMBL
      A6I7W9, A6JAD5
      Conserved Domains (1) summary
      cl12022
      Location:1 → 111
      Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18445.3 GenPept UniProtKB/Swiss-Prot:P18445

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