Pvf3 PDGF- and VEGF-related factor 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pvf3provided by FlyBase
Official Full Name: PDGF- and VEGF-related factor 3provided by FlyBase
Primary source: FLYBASE:FBgn0085407
Locus tag: Dmel_CG34378
See related: AllianceGenome:FB:FBgn0085407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13781; CG13782; CG13783; CG31629; CG34378; CG4492; Dmel\CG34378; DmVEGF-3; Pvf; PVF; pvf3; PVF3; PVFs; VEGF; Vegf27Ca; VEGF27Ca
Old locus tag: CG13783; CG31629; Dmel_CG13783; Dmel_CG31629
Summary: Predicted to enable vascular endothelial growth factor receptor binding activity. Involved in several processes, including hemocyte migration; neurogenesis; and positive regulation of cell size. Acts upstream of with a positive effect on neuron remodeling. Located in extracellular space. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; anlage in statu nascendi; anterior-posterior subdivision of organism; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 27E1-27E3; 2-25 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7098188..7157695, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7098188..7157695, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
Title: Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2.
Data show that Pvf2 and Pvf3 are not required for the directed migration of hemocytes, but act locally in epithelial cells to coordinate trans-epithelial migration of hemocytes.
Title: The Drosophila platelet-derived growth factor and vascular endothelial growth factor-receptor related (Pvr) protein ligands Pvf2 and Pvf3 control hemocyte viability and invasive migration.
PVF1 and PVF3 are specifically deposited within the apical extracellular space of the wing disc
Title: Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in glial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hemocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemocyte migration	IEP Inferred from Expression Pattern more info	PubMed
involved_in hemocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_positive_effect neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PDGF- and VEGF-related factor 3

Names: CG34378-PA; CG34378-PD; CG34378-PE; CG34378-PF; Pvf3-PA; Pvf3-PD; Pvf3-PE; Pvf3-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

7098188..7157695 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298777.1 → NP_001285706.1 PDGF- and VEGF-related factor 3, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285706.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1WWB4, X2J909

Conserved Domains (1) summary

cd00135
Location:451 → 534

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001103638.3 → NP_001097108.1 PDGF- and VEGF-related factor 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097108.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T4M1, Q9VM42

Conserved Domains (1) summary

cd00135
Location:295 → 378

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001103637.3 → NP_001097107.1 PDGF- and VEGF-related factor 3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097107.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1WWB4, Q9VM39

Conserved Domains (1) summary

cd00135
Location:464 → 547

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
NM_001103639.4 → NP_001097109.2 PDGF- and VEGF-related factor 3, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097109.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8T4M1, Q9VM40

Conserved Domains (1) summary

cd00135
Location:282 → 365

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...