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    hupB DNA-binding protein HU [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888166, updated on 6-Oct-2023

    Summary

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    Gene symbol
    hupB
    Gene description
    DNA-binding protein HU
    Locus tag
    Rv2986c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    hlp; hup; lbp21
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    Genomic context

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    Sequence:
    NC_000962.3 (3343176..3343820, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene polyphosphate kinase Neighboring gene 8-oxo-dGTP diphosphatase Neighboring gene 3-isopropylmalate dehydratase small subunit Neighboring gene 3-isopropylmalate dehydratase large subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Iron uptake and transport by the carboxymycobactin-mycobactin siderophore machinery of Mycobacterium tuberculosis is dependent on the iron-regulated protein HupB. Choudhury M, et al. Biometals, 2021 Jun. PMID 33609202
    2. Rv0802c is an acyltransferase that succinylates and acetylates Mycobacterium tuberculosis nucleoid-associated protein HU. Anand C, et al. Microbiology (Reading), 2021 Jul. PMID 34224344
    3. Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight. Green KD, et al. Biochemistry, 2018 Feb 6. PMID 29345920, Free PMC Article
    4. Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization. Ghosh S, et al. Mol Microbiol, 2016 May. PMID 26817737
    5. Direct regulation of topoisomerase activity by a nucleoid-associated protein. Ghosh S, et al. Nucleic Acids Res, 2014. PMID 25200077, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron uptake and transport by the carboxymycobactin-mycobactin siderophore machinery of Mycobacterium tuberculosis is dependent on the iron-regulated protein HupB.
      Title: Iron uptake and transport by the carboxymycobactin-mycobactin siderophore machinery of Mycobacterium tuberculosis is dependent on the iron-regulated protein HupB.
    2. Rv0802c is an acyltransferase that succinylates and acetylates Mycobacterium tuberculosis nucleoid-associated protein HU.
      Title: Rv0802c is an acyltransferase that succinylates and acetylates Mycobacterium tuberculosis nucleoid-associated protein HU.
    3. Biochemical and structural aspects of acetylation of HupB by Eis were measured. Rv1151c from Mtb deacetylated HupB in vitro and the deacetylation kinetics were chracterized. Activities of Eis and Rv1151c could regulate the acetylation status of HupB to remodel the mycobacterial chromosome in response to environmental changes.
      Title: Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.
    4. Rv1151c catalyzes deacetylation of acetylated HU.The DNA binding properties of HU are significantly altered upon acetylation but reversed consequent to deacetylation by the deacetylase.
      Title: A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis.
    5. study demonstrated that the DNA binding property of Mycobacterium tuberculosis HU (MtHU) is regulated by posttranslational modifications akin to eukaryotic histones.
      Title: Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization.
    6. IdeR functioned as the iron regulator, by binding to two IdeR boxes in the hupB promoter.
      Title: Transcriptional regulation of Mycobacterium tuberculosis hupB gene expression.
    7. The results show that a functional coupling between mycobacterial topoisomerase I and MtHU enhances the relaxation activity of the enzyme.
      Title: Direct regulation of topoisomerase activity by a nucleoid-associated protein.
    8. HupB (but not N-terminal or C-terminal domain alone) binds DNA with high affinity, constrains negative DNA supercoiling, introduces negative superhelical turns into relaxed DNA, and inhibits DNA strand exchange promoted by (cognate/noncognate) RecA.
      Title: Synergy between the N-terminal and C-terminal domains of Mycobacterium tuberculosis HupB is essential for high-affinity binding, DNA supercoiling and inhibition of RecA-promoted strand exchange.
    9. The C-terminal region of HupB mediates increased specificity of DNA binding.
      Title: DNA clasping by mycobacterial HU: the C-terminal region of HupB mediates increased specificity of DNA binding.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    DNA-binding protein HU
    NP_217502.1
    • homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3343176..3343820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217502.1 DNA-binding protein HU [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217502.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P9WMK7
      Conserved Domains (1) summary
      COG0776
      Location:1 → 92
      HimA; Bacterial nucleoid DNA-binding protein [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WMK7.1

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