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    Ser12 Serine protease 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ser12provided by FlyBase
    Official Full Name
    Serine protease 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0011832
    Locus tag
    Dmel_CG17240
    See related
    AllianceGenome:FB:FBgn0011832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17240; Dmel\CG17240; SP92
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in wound healing. Orthologous to human KLK13 (kallikrein related peptidase 13); PRSS36 (serine protease 36); and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ser12 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2250431..2251275, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2250431..2251275, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Testis EndoG-Like 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42859 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionary expressed sequence tag analysis of Drosophila spermatheca genes. Prokupek A, et al. Evolution, 2008 Nov. PMID 18752616
    2. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
    3. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377
    4. Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure. Rollmann SM, et al. Genetics, 2008 Jul. PMID 18562639, Free PMC Article
    5. Transcriptional profiling of the sperm storage organs of Drosophila melanogaster. Prokupek AM, et al. Insect Mol Biol, 2009 Aug. PMID 19453766

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 

    General protein information

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    Preferred Names
    serine protease 12
    Names
    CG17240-PA
    Ser12-PA
    NP_523456.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2250431..2251275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078732.2 → NP_523456.1  serine protease 12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0JQ30, Q9VQ97
      Related
      FBpp0077483
      Conserved Domains (2) summary
      smart00020
      Location:23 → 238
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24 → 238
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23986 Q23986
    Q9VQ97 Q9VQ97

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