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    Gpat4 Glycerol-3-phosphate acyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpat4provided by FlyBase
    Official Full Name
    Glycerol-3-phosphate acyltransferase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0034971
    Locus tag
    Dmel_CG3209
    See related
    AllianceGenome:FB:FBgn0034971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3209; dGPAT4; Dmel\CG3209; DmGPAT3/4; GPAT; GPAT4
    Summary
    Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Involved in lipid droplet organization. Located in endomembrane system. Is expressed in adult head. Orthologous to human GPAT3 (glycerol-3-phosphate acyltransferase 3) and GPAT4 (glycerol-3-phosphate acyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gpat4 in Genome Data Viewer
    Location:
    60B8-60B8; 2-106 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24068757..24073552)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19956280..19961075)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ras-associated protein 2-like Neighboring gene yorkie Neighboring gene Muscle LIM protein at 60A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. Valsesia A, et al. Nat Commun, 2019 Feb 1. PMID 30710084, Free PMC Article
    2. Seipin is required for converting nascent to mature lipid droplets. Wang H, et al. Elife, 2016 Aug 26. PMID 27564575, Free PMC Article
    3. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Kory N, et al. Dev Cell, 2015 Aug 10. PMID 26212136, Free PMC Article
    4. Spatial and temporal requirement of Mlp60A isoforms during muscle development and function in Drosophila melanogaster. Wishard R, et al. Exp Cell Res, 2023 Jan 1. PMID 36423661
    5. Drosophila Lipin interacts with insulin and TOR signaling pathways in the control of growth and lipid metabolism. Schmitt S, et al. J Cell Sci, 2015 Dec 1. PMID 26490996

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
      Title: Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
    2. mutation of dGPAT4 is a genetic alteration that triggers such a robust response of the animals to body size challenges in Drosophila
      Title: Ecdysone and insulin signaling play essential roles in readjusting the altered body size caused by the dGPAT4 mutation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    Glycerol-3-phosphate acyltransferase 4
    Names
    CG3209-PB
    CG3209-PC
    CG3209-PD
    CG3209-PE
    Gpat4-PB
    Gpat4-PC
    Gpat4-PD
    Gpat4-PE
    glycerol- 3-phosphate acyltransferase 4
    glycerol-3-phosphate acyltransferase
    NP_001286818.1
    NP_001286819.1
    NP_611880.3
    NP_726415.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24068757..24073552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299890.1 → NP_001286819.1  Glycerol-3-phosphate acyltransferase 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHH1
      Conserved Domains (1) summary
      cd07991
      Location:177 → 356
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    2. NM_001299889.1 → NP_001286818.1  Glycerol-3-phosphate acyltransferase 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGJ9
      Conserved Domains (1) summary
      cd07991
      Location:307 → 513
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    3. NM_138036.4 → NP_611880.3  Glycerol-3-phosphate acyltransferase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611880.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PV17, Q9W1B5
      Conserved Domains (1) summary
      cd07991
      Location:226 → 435
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    4. NM_166658.3 → NP_726415.1  Glycerol-3-phosphate acyltransferase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726415.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R0
      Related
      FBpp0072088
      Conserved Domains (1) summary
      cd07991
      Location:228 → 434
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGJ9 A0A0B4LGJ9
    A0A0B4LHH1 A0A0B4LHH1
    Q960R0 Q960R0
    Q9W1B5 Q9W1B5

    Gene LinkOut

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