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    CG43345 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43345provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263050
    Locus tag
    Dmel_CG43345
    See related
    AllianceGenome:FB:FBgn0263050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9243; Dmel\CG43345
    Old locus tag
    Dmel_CG9243
    Summary
    Predicted to enable single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome. Is expressed in organism. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to several human genes including PLD3 (phospholipase D family member 3) and PLD4 (phospholipase D family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43345 in Genome Data Viewer
    Location:
    39A7-39A7; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21166046..21168581, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21166046..21168581, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene burgundy

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43345-PB
    CG43345-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21166046..21168581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042907.2 → NP_001036372.2  uncharacterized protein Dmel_CG43345, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036372.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R3, Q9VIE9
      Conserved Domains (3) summary
      PHA03003
      Location:87 → 488
      PHA03003; palmytilated EEV membrane glycoprotein; Provisional
      cd09106
      Location:98 → 247
      PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
      cd09107
      Location:300 → 479
      PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins

    2. NM_136252.4 → NP_610096.1  uncharacterized protein Dmel_CG43345, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R3, Q9VIE9
      Related
      FBpp0297826
      Conserved Domains (3) summary
      PHA03003
      Location:87 → 488
      PHA03003; palmytilated EEV membrane glycoprotein; Provisional
      cd09106
      Location:98 → 247
      PLDc_vPLD3_4_5_like_1; Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
      cd09107
      Location:300 → 479
      PLDc_vPLD3_4_5_like_2; Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIE9 Q9VIE9

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