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    PIN8 Auxin efflux carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831362, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIN8
    Official Full Name
    Auxin efflux carrier family protein
    Primary source
    TAIR:AT5G15100
    Locus tag
    AT5G15100
    See related
    Araport:AT5G15100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPIN8; F2G14.220; F2G14_220; PIN-FORMED 8
    Summary
    Encodes an auxin transporter with a strong expression in a male gametophyte. Mutant studies reveal a role for auxin transport in regulating pollen development and function. It acts together with PIN5.
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    Genomic context

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    See PIN8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (4892016..4894113, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene voltage dependent anion channel 3 Neighboring gene Pectate lyase family protein Neighboring gene 2-aminoethanethiol dioxygenase, putative (DUF1637)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structures and mechanism of the plant PIN-FORMED auxin transporter. Ung KL, et al. Nature, 2022 Sep. PMID 35768502, Free PMC Article
    2. Intracellular auxin transport in pollen: PIN8, PIN5 and PILS5. Dal Bosco C, et al. Plant Signal Behav, 2012 Nov. PMID 22990451, Free PMC Article
    3. The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis. Dal Bosco C, et al. Plant J, 2012 Sep. PMID 22540348
    4. Arabidopsis antiporter CHX23 and auxin transporter PIN8 coordinately regulate pollen growth. Gao S, et al. J Plant Physiol, 2021 Nov. PMID 34628190
    5. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Ding Z, et al. Nat Commun, 2012 Jul 3. PMID 22760640

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structures and mechanism of the plant PIN-FORMED auxin transporter.
      Title: Structures and mechanism of the plant PIN-FORMED auxin transporter.
    2. Arabidopsis antiporter CHX23 and auxin transporter PIN8 coordinately regulate pollen growth.
      Title: Arabidopsis antiporter CHX23 and auxin transporter PIN8 coordinately regulate pollen growth.
    3. Data demonstrated a role for PIN8 in intracellular auxin homeostasis.
      Title: Intracellular auxin transport in pollen: PIN8, PIN5 and PILS5.
    4. endoplasmic reticulum-localized PIN8 controls auxin thresholds and access of auxin to the nucleus, thereby regulating auxin-dependent transcriptional activity
      Title: The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis.
    5. ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis.
      Title: ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables auxin efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in auxin export across the plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Auxin efflux carrier family protein
    NP_197014.1
    • PIN-FORMED 8 (PIN8); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity; INVOLVED IN: auxin polar transport, transmembrane transport; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT5G16530.1); Has 2836 Blast hits to 2583 proteins in 784 species: Archae - 43; Bacteria - 1603; Metazoa - 103; Fungi - 0; Plants - 634; Viruses - 0; Other Eukaryotes - 453 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4892016..4894113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121514.2 → NP_197014.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LFP6
      UniProtKB/TrEMBL
      A0A178UI91
      Conserved Domains (1) summary
      pfam03547
      Location:9 → 362
      Mem_trans; Membrane transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFP6.1

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