PGM phosphoglucomutase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PGM
Official Full Name: phosphoglucomutase
Primary source: TAIR:AT5G51820
Locus tag: AT5G51820
See related: Araport:AT5G51820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PHOSPHOGLUCOMUTASE; ATPGMP; MIO24.4; MIO24_4; PGM1; phosphoglucomutase; PHOSPHOGLUCOMUTASE; STARCH-FREE 1; STF1
Summary: Encodes a plastid isoform of the enzyme phosphoglucomutase involved in controlling photosynthetic carbon flow. Effective petiole movement against the direction of the gravity requires functional PGM activity that is required for full development of amyloplasts.
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Genomic context

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See PGM in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 22

Sequence:: Chromosome: 5; NC_003076.8 (21063298..21068327, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIZ1 acts downstream of PGM1 in regulating root hydrotropism.
Title: MIZ1 acts downstream of PGM1 in regulating root hydrotropism.
Cytosolic proline is required for basal freezing tolerance in Arabidopsis.
Title: Cytosolic proline is required for basal freezing tolerance in Arabidopsis.
Growth reduction in the pgm mutant is largely caused by exaggerated root respiration, but not by leaf respiration.
Title: Exaggerated root respiration accounts for growth retardation in a starchless mutant of Arabidopsis thaliana.
Gravitropic mutants phosphoglucomutase (pgm) and sgr9 show abnormal amyloplast distribution and reduced gravitropism at 1 g.
Title: Amyloplast displacement is necessary for gravisensing in Arabidopsis shoots as revealed by a centrifuge microscope.
The focus of this report is the analysis of gravitropic responses in lateral roots of wild-type background and pgm-1 mutants.
Title: Gravitropism in lateral roots of Arabidopsis pgm-1 mutants is indistinguishable from that of wild-type.
pgm-1 roots respond to gravity at one-third the rate of wild-type (WT) roots.
Title: Root cap angle and gravitropic response rate are uncoupled in the Arabidopsis pgm-1 mutant.
Sucrose-inducible genes are upregulated in pgm leaves at the end of a light treatment, when soluble sugars levels are higher than in the wild type.
Title: Identification of sugar-modulated genes and evidence for in vivo sugar sensing in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_124561.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoglucomutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglucomutase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of gravity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within starch biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in stromule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoglucomutase

NP_199995.1

phosphoglucomutase (PGM); FUNCTIONS IN: phosphoglucomutase activity; INVOLVED IN: response to cold, starch biosynthetic process, detection of gravity, carbohydrate metabolic process; LOCATED IN: apoplast, stromule, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Alpha-D-phosphohexomutase, C-terminal (InterPro:IPR005843), Alpha-D-phosphohexomutase, conserved site (InterPro:IPR016066), Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (InterPro:IPR016055), Alpha-D-phosphohexomutase, alpha/beta/alpha domain III (InterPro:IPR005846), Alpha-D-phosphohexomutase, alpha/beta/alpha domain II (InterPro:IPR005845), Alpha-D-phosphohexomutase (InterPro:IPR005841), Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (InterPro:IPR005844); BEST Arabidopsis thaliana protein match is: Phosphoglucomutase/phosphomannomutase family protein (TAIR:AT1G70730.3); Has 12307 Blast hits to 12296 proteins in 2800 species: Archae - 231; Bacteria - 9586; Metazoa - 483; Fungi - 211; Plants - 168; Viruses - 0; Other Eukaryotes - 1628 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

21063298..21068327 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124561.3 → NP_199995.1 phosphoglucomutase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199995.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SCY0

UniProtKB/TrEMBL

A0A178UGL7

Conserved Domains (2) summary

cd03085
Location:70 → 623

PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...

PLN02307
Location:63 → 623

PLN02307; phosphoglucomutase