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    TOP1BETA DNA topoisomerase 1 beta [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835624, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TOP1BETA
    Official Full Name
    DNA topoisomerase 1 beta
    Primary source
    TAIR:AT5G55310
    Locus tag
    AT5G55310
    See related
    Araport:AT5G55310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DNA topoisomerase 1 beta; DNA topoisomerase I alpha; MTE17.2; MTE17_2; TOP1; TOP1ALPHA; TOPOISOMERASE 1
    Summary
    Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality.
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    Genomic context

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    See TOP1BETA in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    16
    Sequence:
    Chromosome: 5; NC_003076.8 (22430105..22435134, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ATPase, V0 complex, subunit E Neighboring gene DNA topoisomerase I alpha Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of a DNA topoisomerase I gene affects morphogenesis in Arabidopsis. Takahashi T, et al. Plant Cell, 2002 Sep. PMID 12215507, Free PMC Article
    2. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124913.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA topological change IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA topoisomerase 1 beta
    NP_200342.1
    • DNA topoisomerase 1 beta (TOP1BETA); FUNCTIONS IN: DNA topoisomerase type I activity; INVOLVED IN: DNA topological change; LOCATED IN: membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase I alpha (TAIR:AT5G55300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22430105..22435134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124913.4 → NP_200342.1  DNA topoisomerase 1 beta [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200342.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJ79
      UniProtKB/TrEMBL
      A0A178UT82, A0A5S9YEC9, A0A654GB65
      Conserved Domains (2) summary
      smart00435
      Location:508 → 884
      TOPEUc; DNA Topoisomerase I (eukaryota)
      pfam02919
      Location:367 → 579
      Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJ79.1

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