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    ASN1 glutamine-dependent asparagine synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823888, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ASN1
    Official Full Name
    glutamine-dependent asparagine synthase 1
    Primary source
    TAIR:AT3G47340
    Locus tag
    AT3G47340
    See related
    Araport:AT3G47340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GLUTAMINE-DEPENDENT ASPARAGINE SYNTHASE 1; AT-ASN1; DARK INDUCIBLE 6; DIN6; glutamine-dependent asparagine synthase 1; GLUTAMINE-DEPENDENT ASPARAGINE SYNTHETASE
    Summary
    encodes a glutamine-dependent asparagine synthetase, the predicted ASN1 peptide contains a purF-type glutamine-binding domain, and is expressed predominantly in shoot tissues, where light has a negative effect on its mRNA accumulation. Expression is induced within 3 hours of dark treatment, in senescing leaves and treatment with exogenous photosynthesis inhibitor. Induction of gene expression was suppressed in excised leaves supplied with sugar. The authors suggest that the gene's expression pattern is responding to the level of sugar in the cell.
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    Genomic context

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    See ASN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (17437840..17441431, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ASN1-encoded asparagine synthetase in floral organs contributes to nitrogen filling in Arabidopsis seeds. Gaufichon L, et al. Plant J, 2017 Aug. PMID 28390103
    2. Starvation-induced expression of autophagy-related genes in Arabidopsis. Rose TL, et al. Biol Cell, 2006 Jan. PMID 16354162
    3. Overexpression of the ASN1 gene enhances nitrogen status in seeds of Arabidopsis. Lam HM, et al. Plant Physiol, 2003 Jun. PMID 12805621, Free PMC Article
    4. Metabolic regulation of the gene encoding glutamine-dependent asparagine synthetase in Arabidopsis thaliana. Lam HM, et al. Plant Physiol, 1994 Dec. PMID 7846154, Free PMC Article
    5. NSR1/MYR2 is a negative regulator of ASN1 expression and its possible involvement in regulation of nitrogen reutilization in Arabidopsis. Nakano Y, et al. Plant Sci, 2017 Oct. PMID 28818378

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that NSR1/MYR2 plays a role in Nitrogen (N) reutilization as a negative regulator through controlling ASN1 expression.
      Title: NSR1/MYR2 is a negative regulator of ASN1 expression and its possible involvement in regulation of nitrogen reutilization in Arabidopsis.
    2. ASN1-encoded asparagine synthetase in floral organs contributes to nitrogen filling in Arabidopsis seeds
      Title: ASN1-encoded asparagine synthetase in floral organs contributes to nitrogen filling in Arabidopsis seeds.
    3. bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
      Title: The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001339306.1
    NM_114602.4
    NM_180332.1
    NM_180333.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables asparagine synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within amino acid catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to sucrose starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to absence of light TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    glutamine-dependent asparagine synthase 1
    NP_190318.1
    • glutamine-dependent asparagine synthase 1 (ASN1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Asparagine synthase (InterPro:IPR001962), Asparagine synthase, glutamine-hydrolyzing (InterPro:IPR006426), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: asparagine synthetase 2 (TAIR:AT5G65010.1); Has 10466 Blast hits to 10069 proteins in 1927 species: Archae - 313; Bacteria - 6097; Metazoa - 215; Fungi - 282; Plants - 342; Viruses - 7; Other Eukaryotes - 3210 (source: NCBI BLink).
    NP_850663.1
    • glutamine-dependent asparagine synthase 1 (ASN1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Asparagine synthase (InterPro:IPR001962), Asparagine synthase, glutamine-hydrolyzing (InterPro:IPR006426), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: asparagine synthetase 2 (TAIR:AT5G65010.2); Has 10371 Blast hits to 9977 proteins in 1906 species: Archae - 313; Bacteria - 6018; Metazoa - 215; Fungi - 282; Plants - 337; Viruses - 5; Other Eukaryotes - 3201 (source: NCBI BLink).
    NP_850664.1
    • glutamine-dependent asparagine synthase 1 (ASN1); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Asparagine synthase (InterPro:IPR001962), Asparagine synthase, glutamine-hydrolyzing (InterPro:IPR006426), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: asparagine synthetase 3 (TAIR:AT5G10240.1); Has 9911 Blast hits to 9877 proteins in 1912 species: Archae - 315; Bacteria - 5703; Metazoa - 210; Fungi - 275; Plants - 333; Viruses - 5; Other Eukaryotes - 3070 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17437840..17441431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114602.4 → NP_190318.1  glutamine-dependent asparagine synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49078
      UniProtKB/TrEMBL
      A0A178VBT4, A0A7G2EQX9
      Conserved Domains (1) summary
      PLN02549
      Location:1 → 578
      PLN02549; asparagine synthase (glutamine-hydrolyzing)

    2. NM_180332.1 → NP_850663.1  glutamine-dependent asparagine synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EQX9, F4JBH5
      Conserved Domains (3) summary
      PRK09431
      Location:1 → 508
      asnB; asparagine synthetase B; Provisional
      cd00712
      Location:2 → 192
      AsnB; Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a ...
      pfam00733
      Location:209 → 508
      Asn_synthase; Asparagine synthase

    3. NM_180333.1 → NP_850664.1  glutamine-dependent asparagine synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JBH6
      Conserved Domains (3) summary
      cd00712
      Location:2 → 192
      AsnB; Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a ...
      TIGR01536
      Location:4 → 416
      asn_synth_AEB; asparagine synthase (glutamine-hydrolyzing)
      pfam00733
      Location:209 → 417
      Asn_synthase; Asparagine synthase

    4. NM_001339306.1 → NP_001326652.1  glutamine-dependent asparagine synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPY0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49078.2

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