ACD11 Glycolipid transfer protein (GLTP) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACD11
Official Full Name: Glycolipid transfer protein (GLTP) family protein
Primary source: TAIR:AT2G34690
Locus tag: AT2G34690
See related: Araport:AT2G34690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACCELERATED CELL DEATH 11; T29F13.10; T29F13_10
Summary: Gene product transports the glycolipid precursor sphingosine between membranes in vitro. Mutant constitutively expresses defense-related genes that accompany the hypersensitive response normally triggered by avirulent pathogens.
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Genomic context

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See ACD11 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (14629986..14632082)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis RING-type E3 ubiquitin ligase XBAT35.2 promotes proteasome-dependent degradation of ACD11 to attenuate abiotic stress tolerance.
Title: Arabidopsis RING-type E3 ubiquitin ligase XBAT35.2 promotes proteasome-dependent degradation of ACD11 to attenuate abiotic stress tolerance.
Phytophthora capsici Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis
Title: A Phytophthora capsici Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis.
In acd11-1 null mutant, normally low ceramide-1-phosphate increases, but phytoceramide rises acutely.
Title: Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels.
Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
Title: Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor.
Lazarus1 (AT4G38360)contributes to programmed cell death associated with acd11 and the hypersensitive response.
Title: Lazarus1, a DUF300 protein, contributes to programmed cell death associated with Arabidopsis acd11 and the hypersensitive response.
ACD11 function could be related to the regulation of membrane compartments.
Title: Identification of proteins interacting with Arabidopsis ACD11.
generated site-specific mutants in ACD11 based on homologous GLTP residues required for glycolipid transfer. We show that these ACD11 mutant forms are impaired in their in vitro transfer activity of sphingolipids
Title: Human GLTP and mutant forms of ACD11 suppress cell death in the Arabidopsis acd11 mutant.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_129023.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingomyelin transfer activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to salicylic acid	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Glycolipid transfer protein (GLTP) family protein

NP_181016.1

ACCELERATED CELL DEATH 11 (ACD11); FUNCTIONS IN: sphingosine transmembrane transporter activity; INVOLVED IN: cell death, defense response to bacterium, incompatible interaction, response to salicylic acid stimulus; LOCATED IN: cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glycolipid transfer protein, GLTP (InterPro:IPR014830); BEST Arabidopsis thaliana protein match is: Glycolipid transfer protein (GLTP) family protein (TAIR:AT4G39670.1); Has 490 Blast hits to 489 proteins in 97 species: Archae - 0; Bacteria - 0; Metazoa - 282; Fungi - 29; Plants - 164; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

14629986..14632082

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129023.5 → NP_181016.1 Glycolipid transfer protein (GLTP) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181016.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A097PRA1, O64587

UniProtKB/TrEMBL

A0A178VMT2, A0A5S9X410

Conserved Domains (1) summary

pfam08718
Location:34 → 170

GLTP; Glycolipid transfer protein (GLTP)