SUC2 sucrose-proton symporter 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SUC2
Official Full Name: sucrose-proton symporter 2
Primary source: TAIR:AT1G22710
Locus tag: AT1G22710
See related: Araport:AT1G22710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA SUCROSE-PROTON SYMPORTER 2; ATSUC2; SUCROSE TRANSPORTER 1; SUCROSE-H+ SYMPORTER; sucrose-proton symporter 2; SUT1; T22J18.12; T22J18_12
Summary: Encodes for a high-affinity transporter essential for phloem loading and long-distance transport. A major sucrose transporter, AtSUC2 can also transport a wide range of physiological and synthetic glucose conjugates with both alpha- or beta-linkage.
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Genomic context

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See SUC2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (8030587..8033156, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of a free hydroxyl group on the coumarin moiety is essential for binding by AtSUC2 and subsequent phloem mobility. Structural modeling of the AtSUC2 substrate-binding pocket explains some important structural requirements for the interaction of coumarin glucosides with the AtSUC2 transporter.
Title: Probing binding specificity of the sucrose transporter AtSUC2 with fluorescent coumarin glucosides.
This observation suggests that under certain environmental conditions, transcriptional regulation may affect the abundance of AtSUC2 and thus regulate the phloem transport velocity.
Title: The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues.
Data indicate that the transcript levels of sucrose transporters AtSUC2, AtSWEET11, AtSWEET12 and AtSWEET15 were significantly higher in stressed roots.
Title: Water Deficit Enhances C Export to the Roots in Arabidopsis thaliana Plants with Contribution of Sucrose Transporters in Both Shoot and Roots.
Data show that rice plants expressing the Arabidopsis phloem-specific Suc transporter (AtSUC2) showed an increase in grain yield of up to 16% relative to wild-type plants.
Title: Enhanced Sucrose Loading Improves Rice Yield by Increasing Grain Size.
AtSUC2 and AtSUC4 are important regulators in plant abiotic stress tolerance that use an abscisic acid (ABA) signaling pathway, which may be crossed with sucrose signaling.
Title: Arabidopsis AtSUC2 and AtSUC4, encoding sucrose transporters, are required for abiotic stress tolerance in an ABA-dependent pathway.
Both SUC1 and Srt1-GFP proteins were found exclusively in phloem companion cells (CCs), only SUC1 complemented the developmental defects of suc2-4 and suc2-5 mutants. [Srt1]
Title: Arabidopsis SUC1 loads the phloem in suc2 mutants when expressed from the SUC2 promoter.
Data indicate that induction of phenolics was suppressed in sucrose transporter mutant plants (suc2-1), indicating that this phenomenon may be controlled, in part, by phloem loading at source leaves.
Title: Temporal changes in allocation and partitioning of new carbon as (11)C elicited by simulated herbivory suggest that roots shape aboveground responses in Arabidopsis.
AtSUC2 transporter is important for retrieval of leaked sucrose in the transport phloem of Arabidopsis.
Title: AtSUC2 has a role for sucrose retrieval along the phloem pathway: evidence from carbon-11 tracer studies.
C-terminal di-leucine motif in INT1 can reroute other proteins, such as INT4, SUCROSE TRANSPORTER2 (SUC2), or SWEET1, to the tonoplast.
Title: Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts.
SUC2 mutants are hypersensitive to N and K deprivation, as well as to decreased levels of overall macronutrients.
Title: Sucrose regulates plant responses to deficiencies in multiple nutrients.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102118.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables sucrose transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables sucrose:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sucrose:proton symporter activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within phloem sucrose loading	NAS Non-traceable Author Statement more info
involved_in sucrose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sucrose transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: sucrose-proton symporter 2

NP_173685.1

sucrose-proton symporter 2 (SUC2); CONTAINS InterPro DOMAIN/s: Sucrose/H+ symporter, plant (InterPro:IPR005989), Major facilitator superfamily MFS-1 (InterPro:IPR011701), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: sucrose-proton symporter 1 (TAIR:AT1G71880.1); Has 2329 Blast hits to 2203 proteins in 568 species: Archae - 32; Bacteria - 908; Metazoa - 423; Fungi - 192; Plants - 420; Viruses - 0; Other Eukaryotes - 354 (source: NCBI BLink).